CASE REPORT article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1662503
This article is part of the Research TopicReviews in Gastroenterology 2025View all articles
Curative endoscopic resection of giant esophageal dedifferentiated liposarcoma: a case report and literature review
Provisionally accepted
- The First Hospital of Jilin University, Changchun, China
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Esophageal dedifferentiated liposarcoma (DDLPS) is extremely rare. We report a case of esophageal dedifferentiated liposarcoma (DDLPS) measuring 12.5 × 3.0 × 2.8 cm in a 62-year-old male presenting with a one-year history of progressive dysphagia. Esophagogastroduodenoscopy and computed tomography showed a large pedunculated submucosal tumor arising from the esophageal entrance and extending intraluminally to 35 cm from the incisor teeth, partially obstructing the esophageal lumen. Curative endoscopic resection was successfully achieved using a novel technique employing an externally placed snare and nylon loop outside the endoscope, thereby avoiding traumatic surgical operation. Histopathologic examination showed that the giant tumor was composed of a differentiated lipomatous component adjacent to dedifferentiated spindle cells. Immunohistochemical analysis revealed spindle cells were positive for p16, CDK4, MDM2, CD34, and CD31. The differentiated lipomatous areas were positive for S-100. The definitive pathologic diagnosis confirmed a dedifferentiated liposarcoma, and the margin was negative. This represents the fifth reported case of esophageal DDLPS successfully managed through endoscopic resection. This externally deployed snare and nylon loop technique provides a viable and less invasive alternative for endoscopic resection of large pedunculated esophageal DDLPS. However, long-term follow-up is necessary to evaluate both therapeutic outcomes and prognosis fully.
Keywords: Liposarcoma, Dedifferentiated, esophageal, Endoscopic resection, histopathological analysis
Received: 09 Jul 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Liu, Wang, Zhang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Nan Zhang, The First Hospital of Jilin University, Changchun, China
Hong Xu, The First Hospital of Jilin University, Changchun, China
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