PERSPECTIVE article
Front. Med.
Sec. Translational Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1663972
From Endoscopy to Surgery: A Translational Perspective on Early Esophageal Cancer Management
Provisionally accepted
- The Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, China
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The management of early-stage esophageal cancer remains suboptimal due to fragmented coordination between endoscopic and surgical modalities, resulting in diagnostic delays and inconsistent therapeutic decision-making. This study presents an integrated clinical framework that synergizes advanced endoscopic techniques (endoscopic submucosal dissection, endoscopic mucosal resection) with thoracic surgical interventions, supported by multimodal staging protocols to improve diagnostic accuracy by approximately 20%. A key innovation is the implementation of a streamlined 72-hour clinical pathway, which reduces treatment delays through real-time multidisciplinary collaboration and intraoperative risk stratification using machine learning-based predictive models. To address systemic barriers, the framework incorporates competency-based cross-disciplinary training programs and value-based reimbursement structures, targeting a 28.7% reduction in treatment discrepancies. Future advancements focus on molecular stratification and health economic evaluations to further refine precision oncology approaches. This paradigm shift from sequential to integrated care demonstrates potential to enhance both oncologic outcomes and healthcare resource utilization in early esophageal cancer management.
Keywords: Translational treatment, esophageal cancer, Endoscopy, Thoracic Surgery, perspective
Received: 11 Jul 2025; Accepted: 04 Sep 2025.
Copyright: © 2025 Pan, Sun, Su and Xiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yan-li Xiu, The Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, China
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