SYSTEMATIC REVIEW article
Front. Med.
Sec. Precision Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1665823
This article is part of the Research TopicExploring Adverse Drug Reactions: Monitoring, Mechanism, Intervention, and ResolutionView all 13 articles
Best Evidence Summary for the Management of Epidermal Growth Factor Receptor Inhibitor–Induced Skin Toxicity Symptoms in Cancer Patients
Provisionally accepted
- 1Burn Department，Ningbo No. 2 Hospital, Ningbo, Ningbo, China
- 2Zhejiang Chinese Medical University, Hangzhou, China
- 3Ningbo No 2 Hospital, Ningbo, China
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【Abstract】Objective To evaluate and summarize the best evidence for management of epidermal growth factor receptor inhibitor-induced skin toxicity symptoms in cancer patients, which aim is at providing reference for medical staff. Methods We systematically searched for evidence on skin toxicity symptoms in databases such as Cnki、Wanfang, some guide websites such as GIN and NZGG, some professional websites such as UICC and ACS. The search time limits from database establishment to July 2024. There were 2 researchers evaluating the quality of the literatures and extracting the data. Results A total of 20 articles were included in this study, including 3 clinical decisions、7 guidelines、3 evidence summary、2 recommended practice and 5 expert consensus. Finally, 27 pieces of evidence were formed from nine aspects: professional medical training, patient health education, precise skin assessment, reducing skin irritation, promoting skin comfort, skin sun protection care, skin moisturizing care, drug preventive measures, and drug treatment measures. Conclusion Our research summarizes the best evidence for management of EGFRI-induced skin toxicity symptoms in cancer patients. In the actual clinical application, it is necessary to fully consider the clinical situation, combine the judgment of professionals and the wishes of patients, follow the principle of individualization, analyze the obstacles and facilitating factors of the application of evidence, and apply the evidence to the clinical practice prudently.
Keywords: Cancer, targeted therapy, Epidermal growth factor receptor inhibitors, skin nursing, summary of evidence
Received: 14 Jul 2025; Accepted: 23 Oct 2025.
Copyright: © 2025 Li, Qiu, Zhang, Zhou, Fan and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiuyue Qiu, 317088276@qq.com
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