SYSTEMATIC REVIEW article
Front. Med.
Sec. Pathology
Global Trends and Perspectives in Mitophagy on Neurodegenerative Diseases: A Scientometric Analysis over 20 Years
Provisionally accepted
- 1First Hospital of Shanxi Medical University, Taiyuan, China
- 2The First People's Hospital of Jinzhong, Jinzhong, China
- 3Taiyuan City Central Hospital, Taiyuan, China
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Background The investigation of mitophagy in neurodegenerative diseases has grown significantly, yet a comprehensive global insight remains limited. This study conducts a scientometric analysis to map the research landscape related to mitophagy in neurodegenerative diseases. Methods We conducted a bibliometric analysis of 2,566 publications (2004 to June 11, 2025) from Web of Science Core Collection and Scopus. To mitigate bias in trend analyses, incomplete 2025 data were excluded from publication growth and curve fitting but retained for other analyses. Data were analyzed via Bibliometrix R package, VOSviewer, Scimago Graphica, and CiteSpace to map mitophagy research evolution. Results The field showed exponential growth with peak productivity in 2021. The United States led publication output, with institutions from the USA,UK, and China forming the core of robust international collaborations, while maintaining the highest citation impact. Influential researchers included Tavernarakis, Nektarios and Reddy, P. Hemachandra, with prominent journals such as International Journal of Molecular Sciences, Cells and Autophagy, serving as key publication venues. Cluster analysis revealed thematic structures centered on "Parkinson's disease," "mitochondrial dysfunction," "oxidative stress," and "fission/fusion mechanisms", with additional focus on "Parkin-mediated mitophagy" and "neurodegenerative diseases". Research evolved from foundational studies through mechanistic exploration to translational applications. Emerging trends include "post-translational modifications (PTMs)," "chaperone-mediated autophagy", "gut microbiota," "mitochondrial quality control," and therapeutic investigations of compounds like "curcumin" and "melatonin". Conclusion This first comprehensive scientometric analysis underscores the expanding interest in mitophagy as a crucial molecular mechanism in neurodegenerative diseases. Our findings establish a framework for developing novel therapeutic interventions such as mitochondrial quality control modulators and compounds like curcumin and melatonin targeting mitophagy dysfunction in neurodegenerative disorders.
Keywords: mitophagy, Neurodegenerative Diseases, Alzheimer's disease, Mitochondrial dysfunction, Oxidative Stress, Pink1/Parkin
Received: 16 Jul 2025; Accepted: 20 Nov 2025.
Copyright: © 2025 Wu, Zhang, Zhanf, Liu and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Haixia Fan, fhxj251@sxmu.edu.cn
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