CASE REPORT article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1667350
Periprosthetic Joint Infection of the Knee Complicated by Primary Localized Cutaneous Amyloidosis: A Case Report
Provisionally accepted
Xinxuan LaiQianjin ZhangFuxin LiuZhiqing XuJinhua GuoHanglin QiuFudong Xu
Zhikun Zhuang
Changyu Huang*- Department of Orthopaedic Surgery, Quanzhou Orthopedic-traumatological Hospital, Quanzhou, China., Quanzhou, China
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Background: Primary localized cutaneous amyloidosis (PLCA) is characterized by amyloid protein deposition in the skin, leading to pigmentation, papules, and itching. The etiology of PLCA remains unclear. Periprosthetic joint infection (PJI) post-total knee arthroplasty (TKA) poses challenges in management. Case Presentation: A PLCA patient underwent TKA and developed acute PJI, necessitating multiple surgical interventions. Recurrence of infection symptoms prompted a two-stage revision surgery approach. Conclusions: Skin lesions in PLCA patients may potentially contribute to the risk PJI following arthroplasty. Strategies such as using tacrolimus for itching management, along with prophylactic antibiotics during PLCA flare-ups, could potentially aid in preventing and managing PJI in this patient population. Further research is needed to elucidate the relationship between PLCA and PJI post-arthroplasty.
Keywords: Primary localized cutaneous amyloidosis, periprosthetic joint infection, Total knee arthroplasty, Treatment, antibiotic
Received: 16 Jul 2025; Accepted: 06 Oct 2025.
Copyright: © 2025 Lai, Zhang, Liu, Xu, Guo, Qiu, Xu, Zhuang and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Changyu Huang, cyhuang0520@126.com
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