REVIEW article
Front. Med.
Sec. Dermatology
Mechanisms of the Subcutaneous Fascia Microenvironment in Skin Scar Formation and Targeted Treatment Strategies
Provisionally accepted
- 1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China
- 2Department of Dermatology, 940th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Lan'zhou, Gansu, China
- 3Max-Planck-Institut fur Herz- und Lungenforschung W G Kerckhoff-Institute, Bad Nauheim, Germany
- 4The University of Hong Kong School of Biomedical Sciences, Hong Kong, Hong Kong, SAR China
- 5Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China
- 6Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- 73201 Hospital, Hanzhong, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Mammals heal wounds and form scars rapidly by mobilizing the matrix components and various cell types in the fascia. Fascial fibroblasts make up about 80% wound cells and migrate with the extracellular gelatinous matrix to the site of injury to form a provisional matrix that rapidly closes the wound. The fascial fibroblasts further differentiate to carry out tissue contraction and remodeling, ultimately forming scars. These findings highlight the importance of the fascial microenvironment in skin scar formation. This article critically reviews the proportion, activation, differentiation, and reduction of fibroblasts in the fascial microenvironment after injury, as well as the characteristics of the fascial matrix and targeted therapeutic strategies.
Keywords: SCAR, fibroblast, wound, Fascial fibroblasts, Scar formation
Received: 16 Jul 2025; Accepted: 30 Oct 2025.
Copyright: © 2025 Wu, Cheng, Zhang, Han, Wang, Yang and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Cuiping Wei, we_cuiping@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.