ORIGINAL RESEARCH article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1667925
This article is part of the Research TopicExploring Immunometabolism: Metabolic Pathway and Immune Response in SepsisView all 9 articles
Prognostic value of systemic immune inflammation and nutritional risk index in septic patients complicated with gastrointestinal dysfunction
Provisionally accepted
- Department of Organ Transplantation Center, Tianjin First Central Hospital, Nankai, China
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Background: Gastrointestinal dysfunction is a common complication in septic patients, exacerbating inflammation and nutritional status. The Systemic Immune Inflammation Index (SII) and Nutritional Risk Index (NRI) show promise as prognostic markers in inflammatory diseases. Therefore, this study aimed to investigate their prognostic value in septic with gastrointestinal dysfunction. Methods: A retrospective analysis was conducted on clinical data from 100 adult patients diagnosed with sepsis complicated with gastrointestinal dysfunction. Baseline characteristics, severity scores, inflammatory markers, nutritional status, and SII/NRI index values were compared between Good Prognosis and Poor Prognosis Groups. The SII and NRI were calculated from peripheral blood cell counts and serum albumin levels. Results: The Poor Prognosis Group exhibited significantly higher levels of inflammatory markers, lower levels of nutritional status markers, and elevated SII, NRI, SII/NRI indexes compared to the Good Prognosis Group. Correlation analysis revealed the associations between these markers and patient prognosis. Logistic regression analysis indicated the independent prognostic value of SII and NRI, while ROC analysis demonstrated the superior predictive capacity of the combined SII/NRI index for adverse prognosis. Conclusion: The SII and NRI, as well as their combined SII/NRI index, hold potential as prognostic markers in patients with sepsis complicated with gastrointestinal dysfunction.
Keywords: prognostic, systemic immune inflammation index, Nutritional risk index, Sepsis, Gastrointestinal dysfunction
Received: 17 Jul 2025; Accepted: 06 Oct 2025.
Copyright: © 2025 Wang, Jin and Dou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lin Dou, dou20240115@163.com
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