ORIGINAL RESEARCH article
Front. Med.
Sec. Translational Medicine
Factors Influencing Therapeutic Efficacy of Non-Lactational Mastitis Based on Hematological Inflammatory Markers and Establishment of a Predictive Model
Provisionally accepted
- 1The Fourth People’s Hospital of Zhenjiang, Jiangsu, China
- 2Changzhou Maternity and Child Health Care Hospital, Jiangsu, China
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Objective: To explore factors influencing the therapeutic efficacy of Non-Lactational Mastitis (NLM) based on hematological inflammatory markers and to establish a predictive model. Methods: 264 cases of NLM patients admitted to The Fourth People's Hospital of Zhenjiang and Changzhou Maternity and Child Health Care Hospital from January 2019 to December 2022 were retrospectively selected. The patients were divided into a modeling group (n=185) and a validation group (n=79) in a 7:3 ratio with a random number table method. In the modeling group, patients were further divided based on therapeutic efficacy into a good efficacy group (n=133) and a poor efficacy group (n=52). Results: The results of binary Logistics regression analysis showed that SII and CRP were influencing factors of therapeutic efficacy of NLM (P<0.05). The formula for the model expression was Logit(P)=-74.457+(0.823X1)+(0.589X2). The calibration curve slope of the model in the modeling group and validation group was close to a straight line, indicating good consistency between the predicted risk and actual risk. The ROC analysis results showed that the area under the curve (AUC) of the model in the modeling group was 0.94(95% CI: 0.823-0.966), The area under the curve of the model in the validation group was 0.85(95% CI: 0.794-0.893), Drawing DCA curves to evaluate the clinical utility of the model in predicting efficacy showed clear positive net benefits, indicating good clinical utility. Conclusion: SII and CRP are influencing factors of therapeutic efficacy of NLM. This study successfully established a prediction model based on hematological inflammatory markers.
Keywords: Inflammatory markers, Non-lactational mastitis, Mastitis, SII, crp
Received: 22 Jul 2025; Accepted: 12 Nov 2025.
Copyright: © 2025 Peng, Li, Fan and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qun Lu, luuqun@126.com
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