REVIEW article
Front. Med.
Sec. Ophthalmology
This article is part of the Research TopicOcular Surgery and Ocular Surface Disease: A Mutual RelationshipView all 4 articles
Surgical Management of Chronic Stevens-Johnson Syndrome
Provisionally accepted
- Dr Shroff Charity Eye Hospital., Delhi, India
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Stevens-Johnson Syndrome (SJS) is a rare but severe mucocutaneous disorder that often leads to chronic ocular complications, requiring a comprehensive and multidisciplinary approach to management. This review outlines the pathophysiology and long-term ocular sequelae of SJS and discusses evidence-based strategies for stabilizing the ocular surface and restoring visual function. Key interventions include punctal occlusion to address tear film instability, mucous membrane grafting (MMG) for lid margin reconstruction, and amniotic membrane transplantation (AMT) to promote epithelial healing and reduce inflammation. Cultivated oral mucosal epithelial transplantation (COMET) and minor salivary gland transplantation (MSGT) serve as advanced options for restoring ocular surface function in severe cases. The correction of cicatricial entropion, often seen in chronic SJS, involves techniques such as anterior lamellar repositioning with or without grafting, which restore lid alignment and reduce ocular trauma. Visual rehabilitation through cataract surgery or keratoprosthesis demands careful preoperative planning due to the fragile ocular surface and heightened risk of postoperative complications. A tailored, staged management plan focused on surface preservation, structural correction, and visual restoration is essential to improve outcomes and quality of life for patients with chronic ocular SJS.
Keywords: Stevens-Johnson Syndrome, Ocular surface disease, Entropion correction, mucous membrane grafting, Amniotic membrane transplantation, dry eye, visual rehabilitation
Received: 19 Jul 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Garg, Gour, Chauhan, Sapra and Sangwan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Virender Singh Sangwan, drsangwan.lvpei@gmail.com
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