ORIGINAL RESEARCH article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1669474
Attenuation of Sepsis-Induced Myocardial Injury by Xiangdan Injection via Mitochondrial Protection and Inflammation Suppression in Mice
Provisionally accepted
- The Third People's Hospital of Hangzhou, Hangzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
ABSTRACT Background: Sepsis-induced myocardial injury (SIMI) is a leading cause of organ dysfunction and mortality in septic patients. Effective myocardial-protective therapies remain limited. Objective: This study evaluated the cardioprotective effects of Xiangdan injection in murine SIMI models caused by both Gram-positive and Gram-negative bacteria. Methods: Male C57BL/6 mice were assigned to sham, sepsis, and three Xiangdan dose groups for each bacterial model using a randomization schedule. Xiangdan injection was administered by oral gavage 12 h before and immediately after bacterial challenge (prophylaxis/early intervention). Outcomes included survival, serum inflammatory cytokines, cardiac biomarkers, histopathology, and ultrastructural mitochondrial integrity. Results: Xiangdan injection markedly improved survival, reduced inflammatory cytokines and cardiac biomarkers, ameliorated myocardial histopathology, and preserved mitochondrial integrity in a dose-dependent manner in both sepsis models (P < 0.05). Conclusion: Xiangdan injection conferred robust cardioprotection in sepsis, combining anti-inflammatory effects, reduction of cardiac injury markers, and preservation of mitochondrial structure. These outcomes are consistent with the known capacity of traditional Chinese medicine formulations to modulate TLR4/NF-κB and JAK2/STAT3 pathways, thereby supporting mechanistic suppression of these cascades in our model.
Keywords: Sepsis-induced myocardial injury, Xiangdan injection, Mitochondrial preservation, inflammatory cytokines, TLR4/NF-κB pathway, JAK2/STAT3 signaling
Received: 19 Jul 2025; Accepted: 14 Oct 2025.
Copyright: © 2025 Li, Chang, Zhang, Pan, Lin and Bai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Li, lihuizdm_126@outlook.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.