ORIGINAL RESEARCH article
Front. Med.
Sec. Pathology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1671323
Red Cell Distribution Width as a Prognostic Indicator in Medical and Surgical ICU Patients
Provisionally accepted
- 1Adiyaman Universitesi, Adıyaman, Türkiye
- 2Istanbul Nisantasi Universitesi, Sarıyer, Türkiye
- 3Istanbul Aydın University, Istanbul, Türkiye
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ABSTRACT Background: Red cell distribution width (RDW) has been investigated as a clinical predictor in different study populations. However, its prognostic usefulness in medical and surgical intensive care units remains unknown. This study investigates the role of RDW as a prognostic factor in this specific patient population. Objective: This study examined the relationship between red cell distribution width and other blood parameters as a prognostic indicator among patients treated in medical and surgical ICU. Method: This study is observational in type and its sample consisted of n=197 patients treated in the medical and surgical ICU (msICU) of a public hospital of Istanbul and during 2023In this study, personal characteristics (age, gender etc.), clinical characteristics (comorbidity, presence of catheters, length of stay etc.) and clinical/laboratory blood parameters (the RDW coefficient of variation (CV), C reactive protein (CRP), albumin, platelet (PLT) etc.) of msICU patients were analyzed. The relationship between clinical/laboratory parameters was examined using the Pearson correlation test, and changes in RDW values according to patient characteristics were examined using ANOVA and independent sample t-tests. Results: In this study a positive, strong and statistically significant relationship existed between RDW and lactate (r=0.704, p=0.004) and CRP (r=0.759, p=0.026), and creatinine (r=0.729, p=0.001). It was reported that a negative, weak and statistically significant relationship existed between RDW and albumin (r=-0.172, p=0.015) and PLT (p=-0.169, p=0.011). The patient characteristics such as inotropic and vasopressor use, multiple comorbidities, APACHE II score, and surgical experience were factors that increased RDW levels (p<0.05). Patients in the postoperative period and patients with pressure sores had higher RDW values and these differences were statistically significant (p<0.05). Conclusion: As a result of this study, RDW level was associated with levels of lactate, CRP, albumin, platelet and creatinine among patients in the medical and surgical ICU. The patients with chronic wounds, comorbidities, and/or certain medications and in deceased patients, were associated with increased RDW. RDW may be a useful marker as a prognostic criterion to validate clinical status.
Keywords: biomarker, Intensive Care Unit, Mortality, prognosis, Red cell distribution width, RDW
Received: 22 Jul 2025; Accepted: 05 Sep 2025.
Copyright: © 2025 Vural, Cinar, Bulbuloglu and Karamelek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Semra Bulbuloglu, Istanbul Aydın University, Istanbul, Türkiye
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