ORIGINAL RESEARCH article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1673496
A Prospective Pilot Study on Plasma Amyloid Beta Oligomers and Postoperative Delirium
Provisionally accepted
- 1Department of Neurology, Soonchunhyang University Hospital Cheonan, Cheonan-si, Republic of Korea
- 2Department of Orthopaedic Surgery, Soonchunhyang University Hospital Cheonan, Cheonan-si, Republic of Korea
- 3Department of Neurology, Hyoja Geriatric Hospital, Yongin-shi, Republic of Korea
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Postoperative delirium (POD) is common in elderly patients and has been associated with Alzheimer's disease (AD). Plasma amyloid-beta oligomers (AβOs) may help clarify this relationship. In this prospective pilot study, 22 patients aged ≥65 undergoing hip or knee arthroplasty under general anesthesia were enrolled. Blood samples were taken pre-and postoperatively to measure of oligomerized amyloid-beta using the multimer detection system(MDS-Oaβ). POD was assessed using the Korean Version of the Delirium Rating Scale-98. Eleven patients developed POD. They were significantly older and had higher preoperative MDS-Oaβ (0.81 vs. 0.56 ng/ml). No significant perioperative change in MDS-Oaβ was observed, suggesting surgery or anesthesia did not affect levels. In the POD group, MDS-Oaβ correlated with both K-DRS-98 severity and total scores. Taken together, these single-center pilot data suggest a link between higher preoperative AβO burden and POD. Given the small sample (N=22), estimates can be imprecise and should be viewed as hypothesis-generating, with confirmation required in larger multicenter cohorts before clinical use.
Keywords: Alzheimer's disease, amyloid-beta oligomers, biomarkers, elderly patients, postoperative delirium
Received: 08 Aug 2025; Accepted: 09 Oct 2025.
Copyright: © 2025 Yang, Jung and Tae Kwak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yong Tae Kwak, kwakdr@gmail.com
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