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CASE REPORT article

Front. Med., 16 October 2025

Sec. Intensive Care Medicine and Anesthesiology

Volume 12 - 2025 | https://doi.org/10.3389/fmed.2025.1675679

This article is part of the Research TopicAdvanced Monitoring in ARDS: Enhancing Mechanical Ventilation through Innovative TechniquesView all 7 articles

Electrical impedance tomography to guide mechanical ventilation for asymmetrical lung injury: a case report

  • Department of Intensive Care, Maasstad Hospital, Rotterdam, Netherlands

During last years, new methods of advanced ventilatory monitoring have been introduced to implement lung-protective ventilation. We present a unique case of a 66-year-old female admitted to the ICU with severe unilateral lung injury due to COVID-19 pneumococcal superinfection. By combining electrical impedance tomography (EIT) and esophageal pressure measurements, individualized positive end-expiratory pressure (PEEP) titration was performed. Initially, high PEEP levels (18 cmH2O) were optimal. Over the course of a week, reflecting dynamic lung recovery, PEEP levels could be reduced to 8 cmH2O followed by extubation. This case emphasizes the importance of personalized PEEP titration in managing asymmetric lung injury, highlighting how EIT-based monitoring can optimize alveolar recruitment while minimizing overdistension.

Introduction

So-called “lung-protective ventilation” is key in critically ill patients undergoing mechanical ventilation. Fundamentally, this would mean low tidal volume, low plateau pressure and low driving pressure (13). However, in asymmetrical lung injury, sufficient PEEP should be administered to recruit the injured lung, while avoiding overdistension of the healthy lung (46). In order to do so, additional information can be obtained with electrical impedance tomography (EIT) and transpulmonary pressure measurements (4, 711). We discuss titrating PEEP for several subsequent days using these techniques in a patient with unilateral lung injury.

Case presentation

We present the case of a 66-year-old Caucasian female patient with a history of untreated B-cell chronic lymphocytic leukemia (CLL), hypertension, and a COVID-19 infection 2 years ago. The patient had a body mass index (BMI) of 31.5, consistent with obesity. The patient was admitted to the Intensive Care Unit (ICU) with hypoxemic respiratory failure due to a pneumococcal pneumonia while having a positive nasopharyngeal swab polymerase chain reaction for SARS-CoV-2. Laboratory tests demonstrated an elevated C-reactive protein of 428 mg/L (normal range 0–10 mg/L) and elevated leukocyte count of 118.5 × 109 (normal range 4.0–10.0 × 109). Chest radiography showed consolidations in the right lung. The initial antibiotic treatment consisted of cefotaxime and ciprofloxacin. Following a negative Legionella antigen test, ciprofloxacin was stopped. Furthermore, the patient was treated with dexamethasone 6 milligrams per day and she received Tocilizumab. Due to suspected insufficient B-cell activity, the patient was also administered COVID-19 convalescent plasma.

Upon admission to the ICU where high-flow nasal oxygen failed (flow 60 L/min, FiO2 1.0, ROX index 2.68), the patient was sedated and intubated. Following intubation, a dual-energy computed tomography (DECT) scan of the chest in supine position revealed extensive consolidation with ground-glass opacities, predominantly affecting the right lung, with no evidence of pulmonary embolism. The DECT findings suggested significant hypoxemic vasoconstriction (Figure 1), predominantly in the right lung. Subsequently, the patient was placed in a prone position to address severe respiratory failure. The first EIT-guided positive end-expiratory pressure (PEEP) trial was then performed in prone position.

Figure 1
CT scan and imaging analysis of the chest in a three-part image. Panel A shows a grayscale CT scan with visible lung structures. Panel B highlights red and black-marked regions indicating perfusion. Panel C displays maps for ventilation, pulmonary perfusion, and V/Q coupling, with color-coded areas and percentages for each map.

Figure 1. Dual-Energy CT in supine position showing the pulmonary window (A) and perfusion overlay (B). Electrical impedance tomography (EIT) on day 4 (C) shows the ventilation and perfusion maps (left) and the ventilation–perfusion (V/Q) map (right), where matched regions appear in green, predominantly ventilated areas in blue, and predominantly perfused areas in red.

Simultaneous advanced respiratory monitoring was performed using esophageal pressure measurements (FluxMed, MBMed, Argentina), with correct catheter positioning confirmed by a Baydur occlusion test ratio of 1.00 and EIT (Enlight 1800/2100, Timpel Medical, São Paulo, Brazil). On days one, two, four, and five, EIT-guided decremental PEEP titration with steps of 2 cmH₂O every 30 s was performed. In our clinical practice, the optimal positive end-expiratory pressure was defined as the PEEP level at the step just before the crossing point, also known as the Costa method; this represents the PEEP setting that minimizes overdistension and collapse (12, 13). This usually results in a collapse below 5%, so we chose a PEEP level with a collapse below 5%. The initial PEEP titration in prone positioning on day 1 (from 20 to 6 cmH₂O) identified an optimal PEEP level of 18 cmH₂O, in prone position. Ventilation parameters over the course of the ICU admission are summarized in Table 1. The median trend and boxplots of PEEP settings and the P/F ratio from onset to ICU discharge are displayed in the Supplementary file.

Table 1
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Table 1. Ventilatory parameters during admission.

After 24 h (day two), the patient was turned to the supine position, and a repeated PEEP titration (from 24 to 12 cmH2O) guided by EIT was performed on the second day, again identifying an optimal PEEP level of 18 cmH₂O. During this titration, a substantial degree of alveolar collapse of 38.5% at the lowest PEEP step and increased overdistension of 40.8% at the highest PEEP step were observed. Notably, after decreasing the PEEP from 24 to 18 cmH2O there was no collapse but from 18 to 16 cmH2O, a sudden increase in alveolar collapse from 0 to 29.6% was detected, coinciding with a decline in respiratory system compliance from 52.2 to 31.4 mL/cmH₂O. Over the following 24 h (day three), the patient remained ventilated with a PEEP of 18 cmH₂O. PEEP titration on day four identified an optimal PEEP of 16 cmH₂O. Additionally, perfusion imaging was conducted through EIT favoring the left lung with a distribution of 34%/66% (right/left) and ventilation distribution of 43%/57% (Figure 1C).

Over the course of the three measurements, a pattern indicative of lung recovery emerged. This was reflected in the changes in alveolar collapse at lowest PEEP level (28.6, 38.5, and 20%), a progressive increase in overdistension at the highest PEEP level (9.8, 40.8, and 45%), and an improvement in highest compliance (47.9, 52.2, and 70 mL/cmH₂O).

On the fifth day, the final EIT-guided PEEP titration was performed, revealing an optimal PEEP of 8 cmH₂O. The abrupt change in the previously set PEEP of 16 cmH₂O and the subsequent EIT-determined optimal PEEP of 8 cmH₂O led to a discussion within the ICU team. Based on P/F ratio, lung compliance, transpulmonary pressure monitoring (PL,EE), and arterial blood gasses, a stepwise PEEP reduction of 2 cmH₂O every 12 h was proposed.

On the same day, the patient successfully transitioned to pressure support ventilation. On day six, effort and transpulmonary pressure were monitored by measuring the ΔPocc (14). Due to the absence of available skilled ICU professionals to measure Delta Pes, airway occlusion pressure was measured as an alternative to assess effort. By day seven, the patient was receiving pressure support ventilation with a PEEP of 8 cmH₂O and a pressure support level of 6 cmH₂O. A spontaneous breathing trial (SBT) was performed, which the patient successfully passed. Following a brief period of continued ventilation, the patient was extubated and started on high-flow nasal oxygen therapy (flow 60 L/min, FiO₂ 0.5). Six days after extubation, the patient was discharged from the ICU.

The four EIT-guided PEEP titrations are graphically represented in Figure 2. The evolution of compliance, collapse and overdistension over time are illustrated in Supplementary Figure S2.

Figure 2
Four line graphs show PEEP trials over days one, two, four, and five. Each graph displays the relationship between PEEP (in cmH2O) and three parameters: collapse (red squares), overdistension (blue circles), and compliance (green triangles). Trends indicate varying patterns of these parameters at different PEEP levels over the days. Compliance generally increases or stabilizes, while collapse and overdistension show opposite trends.

Figure 2. EIT-guided decremental PEEP titrations on Days 1, 2, 4 and 5. The x-axis shows PEEP (cmH₂O) from high (left) to low (right). The left y-axis shows collapse and overdistension (%), and the right y-axis shows compliance (mL/cmH₂O). Curves display collapse (red), overdistension (blue), and compliance (green) for each day.

Discussion

This case highlights the value of near-daily advanced pulmonary monitoring in a mechanically ventilated patient with severe unilateral lung injury. Serial EIT-based PEEP titrations, combined with esophageal pressure measurements, provided important insights into dynamic changes over time and supported individualized management strategies. Computed tomography remains the gold standard for assessing lung aeration (15), but it provides only a static image and involves risks during transport. EIT, in contrast, offers continuous, non-invasive, radiation-free bedside monitoring that can track changes in ventilation and the effects of therapy in real time.

Unilateral lung injury is common in mechanically ventilated patients, and several studies have explored ventilation strategies to optimize oxygenation while minimizing lung injury. Lateral positioning (“good lung down”) may enhance recruitment and improve gas exchange but also carries the risk of atelectasis in dependent regions (46, 16). Prone positioning promotes a more uniform distribution of ventilation by reducing vertical pleural pressure gradients, thereby limiting lung damage (17). These physiological effects explain why prone positioning equalizes regional ventilation and compliance (1719). In our patient, the EIT-derived optimal PEEP was identical in prone and supine (18 cmH₂O), which may reflect persistently elevated pleural pressures associated with obesity (BMI 31.5). In the prone position, ventilation was more evenly distributed between dependent and nondependent lung regions, and this distribution appeared less dependent on PEEP than in the supine position (17, 20). The appearance of airway closing pressure in supine is consistent with less uniform pleural pressure distribution and greater dependent airway compression—reflecting increased chest wall weight and abdominal fat in the supine position (21, 22).

PEEP remains a key parameter in mechanical ventilation, but no consensus exists on the optimal strategy for unilateral injury. Individualized titration guided by EIT has shown promise in balancing recruitment against overdistension, providing real-time functional information at the bedside (8, 2325). Sousa et al. reported that individualized PEEP improved pulmonary hemodynamics and function, especially in bilateral injury, whereas in asymmetric cases optimal PEEP values varied less, but higher PEEP increased overdistension of the non-injured lung (6, 26).

Esophageal pressure (Pes) measurements have also been proposed as a complementary tool. Bastia et al. (4) showed that maintaining an end-expiratory transpulmonary pressure (PL,EE) of 0 cmH₂O promotes a homogeneous distribution of tidal volumes, preventing collapse in the injured lung and hyperinflation in the non-injured lung. In contrast, our findings differed: PL,EE ranged from 0.9 to 3.0 cmH₂O (median 1.5) when PEEP was selected according to the <5% collapse strategy. A likely explanation is that this approach resulted in choosing a PEEP level close to the crossing point, or that the PEEP steps used during titration — particularly the highest and lowest levels applied — influenced the degree of collapse and overdistension (25). Evidence directly comparing EIT- and Pes-guided strategies for individualized PEEP remains limited.

We follow a standardized operating procedure (SOP) for PEEP titration, commencing at 10 cmH₂O above the previous setting, with a minimum of 24 cmH₂O, followed by a decremental trial in 6–8 steps until reduced compliance, oxygen desaturation to <90%, or collapse >10% was observed (to prevent derecruitment). In our patient, the protocol was limited to 20 cmH₂O on day one due to hemodynamic deterioration (ABP 72/58 mmHg, MAP 63 mmHg, desaturation to 79%). On day two, the PEEP trial was performed from 24 cmH₂O down to 12 cmH₂O (Figure 2). We acknowledge that the restricted range of PEEP values may have influenced the EIT-derived optimal PEEP, as algorithms assume that overdistension is 0% at the lowest PEEP and collapse is 0% at the highest step (8). Consequently, the relatively high lowest PEEP level may have underestimated overdistension and shifted the calculated crossing point toward a higher PEEP. This limitation underlines the importance of standardized EIT protocols, as recently emphasized by Scaramuzzo et al. (27). After the 18 cmH₂O PEEP step, collapse suddenly increased from 0 to 30% and reached 40% at 12 cmH₂O. According to our SOP, this high degree of collapse was the reason to terminate the trial at 12 cmH₂O. Based on the shape of the curve, this point most likely represents the airway closing pressure. EIT-guided PEEP titration was not performed on day 3 due to lack of experienced personnel, which may have reduced insight into disease progression. As shown in Supplementary Figure S1, the P/F ratio decreased between days two and three, with improvement after titration on day four. In retrospect, daily PEEP trials would have been preferable. Perfusion–ventilation mismatch measurements were performed only on day 4 (Figure 1C); although consistent with DECT results, conclusions remain limited given the single measurement.

In addition, the patient’s untreated chronic lymphocytic leukemia (CLL) likely contributed to impaired immune responses and increased susceptibility to secondary infection. CLL-associated immunosuppression may have aggravated the severity of the pneumococcal pneumonia and influenced the heterogeneity of lung injury, which could have affected both disease course and ventilatory management.

Barriers to the clinical implementation of EIT include limited availability and the costs of devices and disposables. Nevertheless, potential benefits include reducing the need for transport CT scans and preventing ventilator-induced lung injury. Lung ultrasound (LUS) represents a widely available alternative but also has limitations compared to EIT such as operator-dependency and anatomical limitations. Ongoing research will further clarify the clinical value and broader applicability of EIT in patients with acute lung injury.

Conclusion

This case report describes a patient with severe unilateral lung injury resulting in profound oxygenation impairment. During the first 5 days of intensive care management, advanced monitoring techniques were employed, including PEEP titrations guided by electrical impedance tomography (EIT) and esophageal pressure measurements. Significant fluctuations in lung compliance and alveolar collapse were observed, with optimal PEEP levels ranging between 18 cmH₂O and 8 cmH₂O over the course of treatment. This case highlights the critical role of individualized PEEP titration in adapting to the dynamic changes in lung mechanics in patients intubated for asymmetrical lung injury. Based on this case, daily PEEP titration with advanced monitoring is recommended to optimize PEEP settings, adapt to changes in lung mechanics, and minimize both alveolar collapse and overdistension.

Author’s note

Analyses and plots were generated using R version 4.5.1 (June 2025).

Data availability statement

The original contributions presented in the study are included in the article/Supplementary material, further inquiries can be directed to the corresponding author.

Ethics statement

Ethical approval was not required for the studies involving humans because it describes a single clinical case without experimental intervention. According to institutional policies, case reports that do not involve research procedures or the generation of generalizable data do not require ethics committee review. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.

Author contributions

AM: Data curation, Investigation, Resources, Writing – original draft. LT: Data curation, Investigation, Writing – review & editing. CU: Conceptualization, Supervision, Writing – review & editing. DW: Conceptualization, Data curation, Investigation, Resources, Writing – original draft, Writing – review & editing, Visualization.

Funding

The author(s) declare that no financial support was received for the research and/or publication of this article.

Acknowledgments

This case report was prepared following the CARE Guidelines (28).

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Generative AI statement

The author declares that Generative AI was used in the creation of this manuscript. The authors used OpenAI's ChatGPT (model GPT-4, July 2025 version, available at https://chat.openai.com) to assist with text editing of this manuscript. All content edited using ChatGPT was reviewed by the authors for factual accuracy and originality. ChatGPT was not listed as an author and did not contribute to data interpretation or final conclusions.

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Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Supplementary material

The Supplementary material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmed.2025.1675679/full#supplementary-material

References

1. Amato, MB, Meade, MO, Slutsky, AS, Brochard, L, Costa, EL, Schoenfeld, DA, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med. (2015) 372:747–55. doi: 10.1056/NEJMsa1410639

PubMed Abstract | Crossref Full Text | Google Scholar

2. Grasselli, G, Calfee, CS, Camporota, L, Poole, D, Amato, MBP, Antonelli, M, et al. ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Intensive Care Med. (2023) 49:727–59. doi: 10.1007/s00134-023-07050-7

PubMed Abstract | Crossref Full Text | Google Scholar

3. Brower, RG, Matthay, MA, Morris, A, Schoenfeld, D, Thompson, BT, and Wheeler, A. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. (2000) 342:1301–8. doi: 10.1056/NEJM200005043421801

Crossref Full Text | Google Scholar

4. Bastia, L, Engelberts, D, Osada, K, Katira, BH, Damiani, LF, Yoshida, T, et al. Role of positive end-expiratory pressure and regional Transpulmonary pressure in asymmetrical lung injury. Am J Respir Crit Care Med. (2021) 203:969–76. doi: 10.1164/rccm.202005-1556OC

PubMed Abstract | Crossref Full Text | Google Scholar

5. Bastia, L, Roze, H, and Brochard, LJ. Asymmetrical lung injury: management and outcome. Semin Respir Crit Care Med. (2022) 43:369–78. doi: 10.1055/s-0042-1744303

PubMed Abstract | Crossref Full Text | Google Scholar

6. Sousa, MLA, Menga, LS, Schreiber, A, Docci, M, Vieira, F, Katira, BH, et al. Individualized PEEP can improve both pulmonary hemodynamics and lung function in acute lung injury. Crit Care. (2025) 29:107. doi: 10.1186/s13054-025-05325-7

PubMed Abstract | Crossref Full Text | Google Scholar

7. Cammarota, G, Simonte, R, Longhini, F, Spadaro, S, Vetrugno, L, and De Robertis, E. Advanced point-of-care bedside monitoring for acute respiratory failure. Anesthesiology. (2023) 138:317–34. doi: 10.1097/ALN.0000000000004480

PubMed Abstract | Crossref Full Text | Google Scholar

8. Franchineau, G, Jonkman, AH, Piquilloud, L, Yoshida, T, Costa, E, Rozé, H, et al. Electrical impedance tomography to monitor hypoxemic respiratory failure. Am J Respir Crit Care Med. (2023) 209:670–82. doi: 10.1164/rccm.202306-1118CI

Crossref Full Text | Google Scholar

9. Jonkman, AH, Telias, I, Spinelli, E, Akoumianaki, E, and Piquilloud, L. The oesophageal balloon for respiratory monitoring in ventilated patients: updated clinical review and practical aspects. Eur Respir Rev. (2023) 32:220186. doi: 10.1183/16000617.0186-2022

PubMed Abstract | Crossref Full Text | Google Scholar

10. Grotberg, JC, Reynolds, D, and Kraft, BD. Management of severe acute respiratory distress syndrome: a primer. Crit Care. (2023) 27:289. doi: 10.1186/s13054-023-04572-w

PubMed Abstract | Crossref Full Text | Google Scholar

11. Talmor, D, Sarge, T, Malhotra, A, O'Donnell, CR, Ritz, R, Lisbon, A, et al. Mechanical ventilation guided by esophageal pressure in acute lung injury. N Engl J Med. (2008) 359:2095–104. doi: 10.1056/NEJMoa0708638

PubMed Abstract | Crossref Full Text | Google Scholar

12. Costa, EL, Borges, JB, Melo, A, Suarez-Sipmann, F, Toufen, C Jr, Bohm, SH, et al. Bedside estimation of recruitable alveolar collapse and hyperdistension by electrical impedance tomography. Intensive Care Med. (2009) 35:1132–7. doi: 10.1007/s00134-009-1447-y

PubMed Abstract | Crossref Full Text | Google Scholar

13. Heines, SJH, Becher, TH, van der Horst, ICC, and Bergmans, D. Clinical applicability of electrical impedance tomography in patient-tailored ventilation: a narrative review. Tomography. (2023) 9:1903–32. doi: 10.3390/tomography9050150

Crossref Full Text | Google Scholar

14. Bertoni, M, Telias, I, Urner, M, Long, M, Del Sorbo, L, Fan, E, et al. A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation. Crit Care. (2019) 23:346. doi: 10.1186/s13054-019-2617-0

PubMed Abstract | Crossref Full Text | Google Scholar

15. Ball, L, Scaramuzzo, G, Herrmann, J, and Cereda, M. Lung aeration, ventilation, and perfusion imaging. Curr Opin Crit Care. (2022) 28:302–7. doi: 10.1097/MCC.0000000000000942

PubMed Abstract | Crossref Full Text | Google Scholar

16. Roldán, R, Rodriguez, S, Barriga, F, Tucci, M, Victor, M, Alcala, G, et al. Sequential lateral positioning as a new lung recruitment maneuver: an exploratory study in early mechanically ventilated Covid-19 ARDS patients. Ann Intensive Care. (2022) 12:13. doi: 10.1186/s13613-022-00988-9

PubMed Abstract | Crossref Full Text | Google Scholar

17. Katira, BH, Osada, K, Engelberts, D, Bastia, L, Damiani, LF, Li, X, et al. Positive end-expiratory pressure, pleural pressure, and regional compliance during pronation: an experimental study. Am J Respir Crit Care Med. (2021) 203:1266–74. doi: 10.1164/rccm.202007-2957OC

PubMed Abstract | Crossref Full Text | Google Scholar

18. Guérin, C, Reignier, J, Richard, JC, Beuret, P, Gacouin, A, Boulain, T, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. (2013) 368:2159–68. doi: 10.1056/NEJMoa1214103

PubMed Abstract | Crossref Full Text | Google Scholar

19. Wang, Y, Muhetaer, Y, Zheng, X, Wu, W, Tao, J, Zhu, L, et al. Time-dependent effects of prone position on ventilation-perfusion matching assessed by electrical impedance tomography in patients with COVID-19 ARDS: sub-analysis of a prospective physiological study. Ann Intensive Care. (2025) 15:46. doi: 10.1186/s13613-025-01452-0

PubMed Abstract | Crossref Full Text | Google Scholar

20. Guerin, C, Albert, RK, Beitler, J, Gattinoni, L, Jaber, S, Marini, JJ, et al. Prone position in ARDS patients: why, when, how and for whom. Intensive Care Med. (2020) 46:2385–96. doi: 10.1007/s00134-020-06306-w

PubMed Abstract | Crossref Full Text | Google Scholar

21. Pelosi, P, Croci, M, Ravagnan, I, Tredici, S, Pedoto, A, Lissoni, A, et al. The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia. Anesth Analg. (1998) 87:654–60. doi: 10.1213/00000539-199809000-00031

PubMed Abstract | Crossref Full Text | Google Scholar

22. De Jong, A, Verzilli, D, and Jaber, S. ARDS in obese patients: specificities and management. Crit Care. (2019) 23:74. doi: 10.1186/s13054-019-2374-0

PubMed Abstract | Crossref Full Text | Google Scholar

23. Prins, SA, Weller, D, Labout, JAM, and den Uil, CA. Electrical impedance tomography as a bedside diagnostic tool for pulmonary embolism. Crit Care Explor. (2023) 5:e0843. doi: 10.1097/CCE.0000000000000843

PubMed Abstract | Crossref Full Text | Google Scholar

24. Grassi, LG, Santiago, R, Florio, G, and Berra, L. Bedside evaluation of pulmonary embolism by electrical impedance tomography. Anesthesiology. (2020) 132:896. doi: 10.1097/ALN.0000000000003059

PubMed Abstract | Crossref Full Text | Google Scholar

25. Francovich, JE, Katira, BH, and Jonkman, AH. Electrical impedance tomography to set positive end-expiratory pressure. Curr Opin Crit Care. (2025) 31:319–27. doi: 10.1097/MCC.0000000000001255

PubMed Abstract | Crossref Full Text | Google Scholar

26. Gu, WJ, Zhao, FZ, Piccioni, F, Shi, R, Si, X, Chen, S, et al. Individualized PEEP titration by lung compliance during one-lung ventilation: a meta-analysis. Crit Care. (2025) 29:27. doi: 10.1186/s13054-024-05237-y

PubMed Abstract | Crossref Full Text | Google Scholar

27. Scaramuzzo, G, Pavlovsky, B, Adler, A, Baccinelli, W, Bodor, DL, Damiani, LF, et al. Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions. Crit Care. (2024) 28:377. doi: 10.1186/s13054-024-05173-x

PubMed Abstract | Crossref Full Text | Google Scholar

28. Riley, DS, Barber, MS, Kienle, GS, Aronson, JK, von Schoen-Angerer, T, Tugwell, P, et al. CARE guidelines for case reports: explanation and elaboration document. J Clin Epidemiol. (2017) 89:218–35. doi: 10.1016/j.jclinepi.2017.04.026

PubMed Abstract | Crossref Full Text | Google Scholar

Keywords: lung injury, ventilators, mechanical, electrical impedance tomography, respiratory insufficiency, case report

Citation: Musaj A, Tronchet L, den Uil C and Weller D (2025) Electrical impedance tomography to guide mechanical ventilation for asymmetrical lung injury: a case report. Front. Med. 12:1675679. doi: 10.3389/fmed.2025.1675679

Received: 29 July 2025; Accepted: 30 September 2025;
Published: 16 October 2025.

Edited by:

Francesco Murgolo, University of Bari Aldo Moro, Italy

Reviewed by:

Runshi Zhou, Peking Union Medical College Hospital (CAMS), China
Matthieu Koszutski, Centre Hospitalier Universitaire de Nancy, France

Copyright © 2025 Musaj, Tronchet, den Uil and Weller. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Dolf Weller, d2VsbGVyZEBtYWFzc3RhZHppZWtlbmh1aXMubmw=

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.