ORIGINAL RESEARCH article
Front. Med.
Sec. Hematology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1676874
The Impact of Storage Time on Coagulation Factor Activity in FFP
Provisionally accepted
Rong He1*
Jie Gao1Juan Zhao1Luo Xu1Rui He1Mei Li1Li Wang1Xuemei Liang1Yan Shao1Rong Cheng1Chunbo Xian1Ke Li2- 1Chongzhou People’s Hospital, Chengdu, China
- 2Sichuan University, Chengdu, China
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Objective: This research aims to explore the change law of coagulation factor activity in fresh frozen plasma (FFP) with storage time under standard storage conditions, evaluate the quality change characteristics during its validity period, and provide scientific basis for optimizing the inventory management and turnover strategy of fresh frozen plasma in primary hospitals. Methods: FFP under standard storage conditions (≤ -18℃) was followed up for one year (from the date of collection), and the activated partial thromboplastin time (APTT), prothrombin time (PT), international normalized ratio (INR) and factor Ⅷ (FⅧ) activity at different time points were measured, and the results were analyzed statistically. Results: The PT and APTT of FFP showed an upward trend with the extension of storage time, and remained within the normal reference range, but the growth rate of PT increased after more than 300 days. The activity of FⅧ decreased by 19.35% compared with the baseline level, and the qualified rate was only 72% after 120 days of storage. Conclusion: Under standard storage conditions, the coagulation function indexes (PT, APTT) of FFP remain normal, but the activity of some coagulation factors (such as FⅧ) will decrease significantly with the extension of storage time and inventory management of fresh frozen plasma that been stored nearly 300 days should be enhanced.
Keywords: FFP, blood storage, coagulation factor activity, Coagulation pathway, bloodtransfusion management
Received: 31 Jul 2025; Accepted: 16 Sep 2025.
Copyright: © 2025 He, Gao, Zhao, Xu, He, Li, Wang, Liang, Shao, Cheng, Xian and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rong He, hryisheng@qq.com
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