ORIGINAL RESEARCH article
Front. Med.
Sec. Precision Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1677234
This article is part of the Research TopicAI Innovations in Neuroimaging: Transforming Brain AnalysisView all 10 articles
QBrainNet: Harnessing Enhanced Quantum Intelligence for Advanced Brain Stroke Prediction from Medical Imaging
Provisionally accepted- 1ICFAI Foundation for Higher Education, Hyderabad, India
- 2Koneru Lakshmaiah Education Foundation, Vijayawada, India
- 3Jain University, Bengaluru, India
- 4King Faisal University, Al Ahsa, Saudi Arabia
- 5Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
- 6King Khalid University, Abha, Saudi Arabia
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ABSTRACT: Brain stroke is still one of the leading causes of death and long-term disability in the world. Early and correct diagnosis is therefore important for patient outcome. Although Convolution Neural Network (CNN), classical machine learning models, have achieved great progress in medical image classification, they have to face the performance saturation problem when dealing with high-dimensional and complex data such as medical images. To tackle these limitations, we propose QBrainNet, a quantum enhanced model, which is to enhance brain stroke prediction from medical imaging datasets. The model consists of Quantum Neural Networks (QNNs) applied as learning complex patterns in terms of medical images and Variational Quantum Circuits (VQCs) that will be used to optimize the classification. The feature extraction featured in the QNNs utilises quantum properties of superposition and entanglement to extract non-linear high-dimensional patterns in images related to stroke that may not be captured using classical limits. The VQCs, in turn, are applied to optimize the model performance, further allocating the boundaries of the decision and enhancing the model performance in terms of accuracy by optimizing the quantum gates and operators used during the work. QBrainNet utilizes the combination of such quantum properties as entanglement and superposition to represent more complicated non-linear patterns in stroke-specific images in a better manner than a classical application does. This paper proposes a hybrid classical-quantum scheme: preprocessing classically, and learning quantum-enhanced. Quantum gates and operators are used when performing the quantum phase to optimize decision boundaries, achieving vastly enhanced prediction accuracy and efficiency performance. Experimental results indicate that QBrainNet has a better accuracy (96%) and AUC-PR (0.97) than the classical models like CNN, SVM, and Random Forest, proving the superior performance of QBrainNet in stroke detection. The inference time is shorter, so the model can be used as a real-time clinical application. This article points to the possibilities quantum computing can have in revolutionizing medical diagnostics, especially stroke prediction.
Keywords: Brain stroke prediction, early stroke detection, medical imaging, Quantum computing, Quantum Neural Networks (QNN), Quantum intelligence
Received: 31 Jul 2025; Accepted: 25 Sep 2025.
Copyright: © 2025 Priyadharshini, Murugesh, T R, Albalawi, Saidani and Algarni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mahesh T R, trmahesh.1978@gmail.com
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