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REVIEW article

Front. Med.

Sec. Gene and Cell Therapy

Volume 12 - 2025 | doi: 10.3389/fmed.2025.1678325

This article is part of the Research TopicNext-Generation Gene and Cell Therapies: Targeting Diseases at Their OriginView all articles

AAV Viral Vectors as Therapeutic Interventions for Inherited or Non-inherited Cardiac Disorders: Current Aspects and Future Prospects

Provisionally accepted
  • 1University of Michigan, Ann Arbor, United States
  • 2Bharati Vidyapeeth (Deemed to be University), Pune, India
  • 3University of Pharmaceutical Sciences, Chandigarh, India
  • 4Punjab University, Chandigarh, India
  • 5Graphic Era Deemed to be University, Dehradun, India

The final, formatted version of the article will be published soon.

Abstract: Ischemic and non-ischemic cardiac diseases including arrhythmogenic cardiomyopathy and myocardial infarction, remain one of the leading causes of death worldwide despite significant advances in cardiovascular therapeutics. Current treatment strategies such as β-blockers, angiotensin-converting-enzyme inhibitors, and cardiac surgical interventions that include implantations of pacemakers and cardioverter-defibrillators are effective but often associated with serious side effects. In recent years, multiple cell-based therapies have emerged, aiming either to regeneration of myocardial or myofascial tissues or to correct defective gene using gene-transfer tools. Adeno-associated virus (AAVs), initially identified as contaminants of adeno-virus preparations, have since become one of the most important viral vectors for gene-transfer, especially in mammalian cells. This review analyzes and summarizes various AAV serotypes utilized in gene therapy programs for preclinical and clinical assays for cardiac disease.

Keywords: Tachyarrhythmia, Hypertrophic Cardiomyopathy, ACE inhibitors, β-blockers, EV–encapsulated AAVs

Received: 02 Aug 2025; Accepted: 18 Sep 2025.

Copyright: © 2025 KUMAR, Kalimuthu, Singh, Barnwal and Sharma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Sachin Sharma, sachinhcu07@gmail.com

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