ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1679828
This article is part of the Research TopicNew Concepts, Advances, and Future Trends in Clinical Research on Eye DiseasesView all 60 articles
Global, Regional, and National Burden of Cataract Among Older Adults From 1990 to 2021: A Comprehensive Analysis Based on the Global Burden of Disease Study 2021
Provisionally accepted
- 1Department of Ophthalmology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Tongji University School of Medicine, Shanghai, China
- 2Department of Ophthalmology, Shanghai East Hospital Affiliated to Tongji University, Tongji University School of Medicine, Shanghai, China
- 3Department of Ophthalmology, Shanghai Eighth People’s Hospital, Shanghai, China
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Objective: To assess the global, regional, and national burden of cataract among individuals aged 60 years and older from 1990 to 2021, and to examine disparities by age, sex, socio-demographic level, and geographic region using data from the Global Burden of Disease Study (GBD) 2021. Methods: We extracted cataract prevalence data for 204 countries from GBD 2021 and analyzed age-standardized prevalence rates (ASPRs) across regions and Socio-demographic Index (SDI) levels. Sex- and age-specific patterns were assessed. Age-period-cohort modeling, decomposition analysis, absolute and relative inequality metrics, and frontier analysis were applied to assess temporal trends, demographic drivers, and disparities. Results: In 2021, the global ASPR of cataract among the elderly was 7,748.5 per 100,000, with significantly higher rates in South Asia. Females had consistently higher ASPRs than males across all age groups and regions. Prevalence increased with age, peaking in those aged ≥95 years. APC analysis revealed that aging is the dominant driver of burden, with minor period and cohort effects. Decomposition showed that global prevalence increases were largely driven by population growth (87.4%), with smaller contributions from aging and epidemiological change. Substantial inequality persisted: low-SDI countries bore disproportionately higher burdens, with minimal improvement from 1990 to 2021. Frontier analysis revealed large performance gaps even among similarly developed countries. Conclusion: Cataract remains a major and unequal public health burden among older adults, particularly in low- and middle-SDI settings. Addressing service delivery inefficiencies, expanding surgical coverage, and implementing equitable aging-focused eye care policies are essential to reduce avoidable visual impairment globally.
Keywords: Cataract, older adults, Global burden of disease, Age-standardized prevalence, health inequality
Received: 05 Aug 2025; Accepted: 21 Aug 2025.
Copyright: © 2025 Wan, Bai, Wang and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qing Peng, Department of Ophthalmology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Tongji University School of Medicine, Shanghai, China
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