ORIGINAL RESEARCH article
Front. Med.
Sec. Translational Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1681440
An Experimental Study on the Pollen Particle Blocking Efficacy of a Barrier Nasal Mask
Provisionally accepted
- Shaanxi Provincial People's Hospital, Xi'an, China
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Objective: To explore the blocking effect of a barrier nasal mask composed of bionic nasal hair combined with a blocking gel on allergen particles in a 1:1 3D-printed nasal cavity model and to provide new ideas for the clinical prevention and treatment of allergic rhinitis. Methods: A 1:1 scale 3D-printed nasal cavity model was constructed, and dust-free paper was placed at specific anatomical locations within the model. The experimental group was defined as those wearing a nasal mask, whereas the control group did not wear a nasal mask. A simple breathing bag was used to simulate normal respiration, and a pneumatic nebulizer was employed to introduce stained Artemisia annua pollen. The simulated breathing experiments were conducted for 15 minutes and 30 minutes. The degree of staining on the dust-free paper in both groups was observed and scored. Results: At 15 minutes, the median (25th, 75th percentiles) total scores for all anatomical sites in the nonblocking group and blocking group were 3 (2, 4) and 0 (0, 1), respectively (Z=-9.094, P <0.001). At 30 minutes, the total scores of the two groups were 4 (2, 5) and 1 (0, 2), respectively (Z=-9.062, P <0.001). Additionally, the comparison of scores at all other individual anatomical sites revealed P <0.001. Conclusion: This barrier nasal mask can effectively reduce pollen particle deposition at various anatomical sites in the nasal cavity. The crossover test using the same model verified the reliability of its blocking efficacy, which suggests that it is a potential innovative intervention for the prevention of allergic rhinitis.
Keywords: Barrier nasal mask, Bionic nasal hair, Allergen-blocking gel, 3D-printednasal cavity model, allergic rhinitis
Received: 07 Aug 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Zhang, lu, Zhao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jinping Wang, 306070789@qq.com
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