ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1681557
This article is part of the Research TopicNew Concepts, Advances, and Future Trends in Clinical Research on Eye DiseasesView all 69 articles
Comparison of Two Main Orthokeratology Lens Designs in Effectiveness and Safety for Myopia Control in different age
Provisionally accepted
- 1Department of Ophthalmology, Affiliated Hospital of Guizhou Medical University, Guiyang, China
- 2Guizhou Medical University, Guiyang, China
- 3Guizhou Nursing Vocational College, Guiyang, China
- 4Guizhou Bright Eye Hospital, Guiyang, China
- 5The Affiliated Hospital of Guizhou Medical University, Guiyang, China
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Purpose: Myopia represents the most prevalent ocular condition among children and adolescents worldwide, exhibiting marked variations in prevalence across regions and ethnic groups. This study aimed to assess and compare the effectiveness and safety of two orthokeratology (OK) lens types—corneal refractive therapy (CRT) and vision shaping treatment (VST)—for controlling myopia progression across different age groups. Methods: A retrospective cohort analysis was performed on 105 pediatric patients (210 eyes; aged 8–16 years) clinically diagnosed with myopia who wore CRT or VST lenses for at least 12 months. Longitudinal evaluations included axial length (AL) progression, axial length-to-corneal curvature (AL/CR) ratio, corneal curvature, corneal eccentricity indices (e-values), and safety parameters. Results: CRT lenses markedly limited AL elongation and reduced corneal curvature flattening in participants younger than 13 years (P < 0.0001), whereas VST lenses produced more favorable changes in E-values among those older than 11 years (P < 0.05). No significant difference was observed between groups in AL/CR ratio control (P > 0.05). Both lens designs maintained similar safety outcomes, with only mild corneal epithelial staining detected across all groups. Conclusions: The results reveal age-dependent variations in effectiveness, supporting an individualized approach to OK lens selection for optimized myopia management.
Keywords: Orthokeratology, Myopia control, CRT lenses, VST lenses, Axial length, corneal curvature
Received: 07 Aug 2025; Accepted: 09 Oct 2025.
Copyright: © 2025 Li, Yang, He, Yang, Liu and Ou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shangkun Ou, shangkun_ou@126.com
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