CASE REPORT article
Front. Med.
Sec. Rheumatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1683606
This article is part of the Research TopicImpact of Autoimmune Rheumatic Diseases on Respiratory Tract Health and Advancing CareView all 4 articles
Progressive Interstitial Lung Disease secondary to Sjögren's Disease in a patient with Inclusion Body Myositis Complicated by Dysphagia: A Multidisciplinary Approach and Therapeutic Challenges
Provisionally accepted
Emanuele Cocchiara1*
Francesca Cozzini1,2Ilaria Chiapparoli1Francesco Falco1Gianluigi Bajocchi1
Carlo Salvarani1,2
Andreina Manfredi1,2- 1Arcispedale Santa Maria Nuova di Reggio Emilia, Reggio Emilia, Italy
- 2University Hospital of Modena, Modena, Italy
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We present the case of a 78-year-old man with a complex overlap of inclusion body myositis (IBM) and Sjögren's Disease (SjD), complicated by interstitial lung disease (ILD) and esophageal dysfunction. The patient's neuromuscular decline was managed with periodic intravenous immunoglobulins (IVIG), while his progressive ILD required a combined immunosuppressive and antifibrotic regimen, also including prednisone. This case underscores the diagnostic and therapeutic challenges in managing autoimmune overlap syndromes, particularly the rare coexistence of IBM and SjD-related ILD. We highlight the rationale behind the treatment strategy and the importance of a tailored, multidisciplinary approach in addressing both muscular and pulmonary manifestations.
Keywords: inclusion body myositis, Sjögren's disease, Interstitial Lung Disease, Nintedanib, dysphagia
Received: 11 Aug 2025; Accepted: 22 Oct 2025.
Copyright: © 2025 Cocchiara, Cozzini, Chiapparoli, Falco, Bajocchi, Salvarani and Manfredi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Emanuele Cocchiara, emanuele.cocchiara@ausl.re.it
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