ORIGINAL RESEARCH article
Front. Med.
Sec. Translational Medicine
Preliminary study on the influencing factors of Young's modulus of viscoelastic model detected by shear wave elasticity
Provisionally accepted
- 1Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China
- 2The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
- 3Lishui Central Hospital, Lishui, China
- 4The First Affiliated Hospital of Ningbo University, Ningbo, China
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Aim: The objective of this study is to investigate the influence of various components, viscosity, ultrasonic frequency, and depth of the region of interest on the Young's modulus of the viscoelastic model. Methods: Viscoelastic models, characterized by distinct viscosities and compositions, were fabricated using gelatin as the elastomeric component, fructose as the viscous component, and milk powder as an additive ingredient. Shear wave elastography (SWE) technology was utilized, with the acoustic frequencies set at 7MHz, 8MHz, and 9MHz respectively. Additionally, the depths of regions of interest (ROI) were varied at 1cm, 2cm, and 3cm to enable a comparison of Young's modulus values across different viscoelastic body models. Results: In order to generate viscoelastic models with varying compositions, gelatin samples of with the same concentration were prepared with different concentrations of fructose added. Under consistent frequency and ROI depth conditions, no statistically significant differences were observed in the measured Young's modulus values among these models (p>0.05). However, for models composed solely of gelatin, significant differences in Young's modulus values were noted at varying sound wave frequencies and ROI depths (p<0.05). When samples with different fructose and powdered milk compositions and concentrations were prepared at a constant gelatin concentration, a range of viscoelastic models with diverse properties was created. Analysis of the Young's modulus values at varying sound wave frequencies and ROI depths revealed a statistically significant difference for all model groups when the frequency was 8MHz
Keywords: Shear wave elasticity, viscoelastic model, Viscosity, influencing factor, Ultrasonic frequency
Received: 13 Aug 2025; Accepted: 11 Nov 2025.
Copyright: © 2025 Wu, Xu, Wang, Chen, Zhou, Zhou, Zou, Huang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yanhua Huang, huangyh_edu@outlook.com
Ying Li, 312594723@qq.com
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