CASE REPORT article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1690559
Case report: Successful treatment of severe bronchiectasis by inhalation of mesenchymal stem cell-derived exosomes
Provisionally accepted
- China Academy of Chinese Medical Sciences Guang'anmen Hospital, Beijing, China
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Bronchiectasis is a chronic respiratory disorder characterized by irreversible airway dilation and recurrent infections, remains a therapeutic challenge. MSCs-exosomes based treatment is a potential treatment for respiratory disease; however, data regarding the efficacy of this novel therapy are currently lacking. We present a case of bronchiectasis treated with inhaled exosomes derived from human umbilical cord mesenchymal stem cells. As demonstrated in this patient, MSCs-exosomes inhalation may provide comprehensive benefits including reversal of hypoxemia, which could potentially result in enhancement of clinical outcomes and quality of life, and reduction in mortality.
Keywords: Bronchiectasis, Inhalation, Exosomes, Mesenchymal Stem Cells, case report
Received: 27 Aug 2025; Accepted: 09 Oct 2025.
Copyright: © 2025 Liu, Xia, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guangxi Li, lgx0410@163.com
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