CASE REPORT article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1693184
This article is part of the Research TopicTumor Microenvironment and Personalized Therapy of Gastrointestinal Cancer ⅡView all articles
Malignant Transformation of Gastric Hyperplastic Polyps in an Autoimmune Gastritis Patient—a Case Report and Literature Review
Provisionally accepted
- Xuanwu Hospital, Capital Medical University, Beijing, China
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The cancer risk in autoimmune gastritis (AIG) remains controversial. Malignant transformation of gastric hyperplastic polyps (GHPs) in an AIG patient is rare. The esophagogastroduodenoscopy (EGD) of a 75-year-old male patient showed a 0.8 cm GHP. Endoscopic resection was conducted, and the pathological findings showed high-grade dysplasia and intramucosal moderately differentiated adenocarcinoma. Follow-up at 1 year confirmed no sign of recurrence. 18 months post-operatively, another EGD confirmed advanced-stage AIG, evidenced by characteristic endoscopic/histologic findings, positive anti-parietal cell antibody, low pepsinogen I/II ratio, significantly elevated gastrin-17, low vitamin B12, and negative Helicobacter pylori (Hp) serology. Concurrent Hashimoto's thyroiditis and vitiligo were also noted. We here report a rare case of early malignant transformation of a small GHP arising in a context of AIG. Elevated gastrin levels may be a potential risk factor for cancer development in Hp-negative AIG. Endoscopic resection can be considered for early-stage cancerous transformation of GHPs.
Keywords: Gastric hyperplastic polyps, gastric cancer, endoscopic mucosal resection, Autoimmune gastritis, case report
Received: 26 Aug 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Wang, Liu, Hong, Cai, She and Zhai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui-Hong Zhai, nxykdx1009@163.com
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