ORIGINAL RESEARCH article
Front. Med.
Sec. Gastroenterology
This article is part of the Research TopicResearch on Biomarkers for Immunotherapy in Gastrointestinal Tumors: Basic Exploration and Clinical ApplicationView all 6 articles
Perioperative Nursing Coordination and Complication Management in Yttrium-90 Radioactive Microsphere Therapy for Hepatocellular Carcinoma
Provisionally accepted
Xian Li
Qiangwei Shang*- Department of Hepatobiliary Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, China, Jinan, China
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To explore the perioperative nursing protocols and complication management strategies for hepatocellular carcinoma (HCC) patients undergoing Yttrium-90 (Y-90) radioactive microsphere therapy. Methods: A retrospective analysis was performed on clinical data from 15 HCC patients treated with Y-90 radioactive microspheres at Qilu Hospital of Shandong University between December 2024 and April 2025. A structured, multidisciplinary perioperative nursing protocol was implemented, consisting of: (1) Preoperative multidisciplinary evaluation including nutritional risk screening (NRS-2002), radiation dosimetry assessment, and vascular anatomy verification; (2) Intraoperative coordination with specific steps for patient positioning, vascular access establishment, radiation safety measures, and vital sign monitoring; (3) Postoperative dynamic monitoring of vital signs (every 2 hours), puncture site condition, laboratory parameters (at 24h and 72h), and symptom assessment using NRS for pain; (4) Tiered complication management system based on CTCAE v5.0 grading criteria. All 15 patients completed the treatment successfully. The postoperative complication rate was 73.3% (11/15), with manifestations including abdominal pain (5 cases), fatigue (3 cases), leukopenia (3 cases), thrombocytopenia (2 cases), and low-grade fever (1 case), all complications resolved with appropriate symptomatic management. No severe adverse events such as radiation-induced liver injury or significant myelosuppression occurred. Standardized perioperative nursing workflows, comprehensive radiation protection protocols, and an early-warning system for complications are essential to enhancing the safety of Y-90 microsphere therapy.
Keywords: Yttrium-90 microspheres, Hepatocellular Carcinoma, interventional radiology, Perioperative Nursing, Complication management
Received: 28 Aug 2025; Accepted: 19 Nov 2025.
Copyright: © 2025 Li and Shang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiangwei Shang, 675012058@qq.com
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