SYSTEMATIC REVIEW article
Front. Med.
Sec. Rheumatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1694721
Risk factors of osteonecrosis in patients with systemic lupus erythematosus: a meta-analysis
Provisionally accepted
Xiang Zhou*
Yijie Chai- department of Internal Medicine, epartment of Internal Medicine I, Xianju Hospital of Traditional Chinese Medicine, Zhejiang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: To explore risk factors for osteonecrosis in patients with systemic lupus erythematosus by meta-analysis. Methods: PubMed, Embase, web of science, Cochrane library were searched for case-control/cohort studies on the occurrence of osteonecrosis in patients with systemic lupus erythematosus from the time the database was created until 1 December 2024. Data were analyzed using Stata 15.0, and the quality of the included studies was evaluated using the NOS score. Result: A total of 14 articles including 3890 patients were included, meta-analysis indicate that younger SLE patients [SMD = -0.23, 95% CI (-0.39, -0.06)], diabetes mellitus [OR = 1.78, 95% CI (1.03, 3.09)], hypertension [OR = 1.33, 95% CI (1.03, 1.72)], arthritis [OR = 1.57, 95% CI (1.24, 2.00)], Raynaud's phenomenon [OR = 1.76, 95% CI (1.35, 2.30)], and cyclophosphamide [OR = 2.24, 95% CI (1.38, 3.63)] were risk factors for the development of osteonecrosis in patients with SLE. Conclusion: The current study found that younger age, hypertension, diabetes, arthritis, Raynaud’s phenomenon, and cyclophosphamide use were identified as independent risk factors for the development of osteonecrosis in patients with SLE.
Keywords: systemic lupus erythematosus, Osteonecrosis, Risk factors, Meta-analysis, Systematic review
Received: 28 Aug 2025; Accepted: 29 Sep 2025.
Copyright: © 2025 Zhou and Chai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiang Zhou, doczhou2024@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.