REVIEW article
Front. Med.
Sec. Rheumatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1695572
Evaluation of Tonsillectomy in the Treatment of SAPHO Syndrome: Past Evidence and Future Directions
Provisionally accepted
- 1Qinghai University Affiliated Hospital, Xining, China
- 2Peking Union Medical College Hospital, Beijing, China
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SAPHO syndrome is a rare aseptic inflammatory clinical syndrome characterized by widespread skin lesions and bone-joint lesions. The underlying mechanisms remain unclear, making it difficult to treat. Currently, drug-based symptomatic treatment is the main approach, but symptoms often recur or worsen when medications are reduced or discontinued. Recently, there have been increasing reports of the significant therapeutic effects of tonsillectomy in treating SAPHO syndrome. This paper reviews the past evidence on the use of tonsillectomy for SAPHO syndrome by searching PubMed, Google Scholar, Web of Science, Embase, Scopus, CNKI, and Wanfang databases using the keywords "SAPHO syndrome and tonsillectomy". It also discusses the potential mechanisms of tonsillectomy in treating SAPHO syndrome, aiming to provide new treatment methods for SAPHO syndrome.
Keywords: SAPHO syndrome, Treatment, Tonsillectomy, Ppalmoplantar pustular psoriasis, Synovitis, Acne, Hyperostosis, Osteomyelitis
Received: 30 Aug 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Gan, Ren, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Wang, wegreatgroup@126.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.