CASE REPORT article
Front. Med.
Sec. Dermatology
Wolf's Isotopic Response of Eczema after Herpes Zoster Infection:Case Report and Literature Review
Provisionally accepted
- 1The first clinical Medical College, Shanxi medical university, Taiyuan, China
- 2Department of Dermatology, First Hospital of Shanxi Medical University, Taiyuan, China
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Wolf's post-herpetic isotopic response (PHIR) refers to the development of new cutaneous conditions, such as tumors, infections, or immune-mediated diseases, at the site of a previously healed herpetic eruption(2). The exact pathogenesis of Wolf's PHIR remains incompletely understood. Four hypotheses have been proposed regarding the mechanism of postherpetic inflammatory isomorphic reactions: viral, immunological, vascular, and neurological.In this case, we show that a patient with eczema that developed at the original site following the resolution of herpes zoster infection. After two weeks of systemic oral glucocorticoid treatment, the skin lesions improved significantly, and there was no recurrence during the three-month follow-up.
Keywords: Herpes Zoster, Eczema, Wolf's isotopic response, Neuropeptides, Th2-typeimmune responses
Received: 01 Sep 2025; Accepted: 11 Nov 2025.
Copyright: © 2025 Zhao, Zhang, Chen, Guo and Hongye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shuping Guo, gsp6688@sina.com
Liu Hongye, blewsnow168@sina.com
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