CASE REPORT article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
A rare case of Clostridium paraputrificum bloodstream infection in patients with intestinal necrosis: a case report and literature review
Provisionally accepted
- 1People’s Hospital of Deyang City, Deyang, China
- 2Yongchuan District People's Hospital of Chongqing, Chongqing, China
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Bloodstream infections caused by anaerobic bacteria present a serious threat to patients. Rapid and accurate diagnosis is crucial for treatment and patient prognosis. Herein, we report a rare case of Clostridium paraputrificum bacteremia in an 82-year-old female patient who developed an infection after undergoing necrotic small bowel resection. The patient was treated with 5-day anti-infective therapy with meropenem and linezolid, successfully controlling the disease. We also constructed a phylogenetic tree with other similar bacteria using gene sequencing and showed the virulence and antimicrobial resistance of C. paraputrificum. Additionally, the Clinical features and antibiotic treatment of this case were reviewed and discussed with existing literature. This case and review illustrate the insidious nature of C. paraputrificum infections, emphasizing the need for greater clinician awareness and improved diagnostic and treatment strategies.
Keywords: Clostridium paraputrificum, anaerobic bloodstream infections, necroticsmall bowel resection, case report, Whole-genome sequencing, LiteratureReview
Received: 10 Sep 2025; Accepted: 14 Nov 2025.
Copyright: © 2025 Jiang, Ji, Wang, Zongyao, E, Huang and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yayun Jiang, dyjiangyayun@163.com
Zi Qian Huang, hzq-fy25@outlook.com
Wei Huang, 1337539781@qq.com
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