REVIEW article
Front. Med.
Sec. Pathology
Recent Progress in the Clinicopathological Characteristics of Alveolar Soft Part Sarcoma
Provisionally accepted
- 1Mudanjiang Cancer Hospital, Mu Danjiang, China
- 2Department of pediatric Surgery,Hong Qi Hospital affiliated to Mudanjiang Medical University, Mudanjiang, China
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Alveolar Soft Part Sarcoma (ASPS) is a rare malignant soft tissue neoplasm char acterized by distinctive histological features, indolent growth patterns and a propensity for metastasis. Recent advancements in molecular pathology and targeted therapies have signifi cantly enhanced our understanding of its clinical and pathological characteristics. This pape r systematically reviews the epidemiological profile, histopathological diagnostic criteria, m olecular genetic mechanisms (notably the ASPSCR1-TFE3 gene fusion), immunophenotypic features, and differential diagnosis of ASPS. By integrating insights from multi-omics tech nologies, we explore the potential of personalized diagnostic and therapeutic strategies to i mprove disease comprehension and refine clinicopathological diagnostic standards, thereby guiding clinical management and enhancing patient outcomes.
Keywords: Alveolar soft part sarcoma, TFE3 gene fusion, Immunohistochemistry, Pathology, asps
Received: 11 Sep 2025; Accepted: 27 Nov 2025.
Copyright: © 2025 Cong, Shi, Zhang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qingyu Xu
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