MINI REVIEW article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1709710
The Role of Pulmonary Rehabilitation in severe Asthma: A Comprehensive Review
Provisionally accepted
- 1University of Padua, Padua, Italy
- 2Department of Cardiac-Thoracic-Vascular Sciences and Public Health, Respiratory Pathophysiology Unit, Padua, Italy
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Background: Severe asthma remains a major problem despite pharmacological advances. Pulmonary rehabilitation (PR) is established in chronic respiratory disease but its role in severe asthma is unclear. Objectives: Summarise evidence on PR in severe and uncontrolled asthma, describe PR-modalities, and outline implementation and research priorities. Methods: Narrative review of systematic reviews and clinical studies of multidimensional PR programmes and isolated components (aerobic training, inspiratory muscle training [IMT], breathing retraining, neuromuscular electrical stimulation [NMES], telerehabilitation). Outcomes included asthma control, HRQoL, exercise capacity and healthcare utilisation. Results: Multicomponent PR improves exercise capacity and multiple QoL domains; pooled data show substantial increases in six-minute walk distance. Combined exercise, education and self-management produced clinically meaningful improvements in asthma control and symptoms, notably patients with uncontrolled disease and functional impairment. IMT, NMES and breathing retraining improved inspiratory strength, peripheral muscle function and hyperventilation symptoms. Telerehabilitation expands access but requires attention to digital literacy and adherence. Heterogeneity, small samples and attrition limit generalisability. Conclusions: PR is a promising personalised, multidisciplinary adjunct for severe asthma. Larger phenotype-stratified trials, harmonised outcome sets and implementation research are needed to define candidate selection, optimal dose and cost-effectiveness; embedding PR within severe asthma centres may optimise outcomes and reduce healthcare use.
Keywords: aerobic training, Inspiratory muscle training, Breathing retraining, telerehabilitation, Maintenance strategies
Received: 20 Sep 2025; Accepted: 13 Oct 2025.
Copyright: © 2025 Guarnieri, Pozza and Vianello. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gabriella Guarnieri, gabriella.guarnieri@unipd.it
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