ORIGINAL RESEARCH article
Front. Med.
Sec. Obstetrics and Gynecology
This article is part of the Research TopicImpact of Physical Activity on Women's Health and Quality of Life: Focusing on Maternal Health and pregnancy OutcomesView all 5 articles
Application of Thromboelastogram and Coagulation function in Evaluating Coagulation status of pregnant Women across different Trimesters
Provisionally accepted
- 1Clinical Laboratory, Zhangjiagang Second People's Hospital, Zhangjiagang, China
- 2Department of Obstetrics and Gynecology, Zhangjiagang Second People's Hospital, Zhangjiagang, China
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Background: Pregnancy induces a hypercoagulable state to prevent hemorrhage during delivery, but it also increases the risk of thrombotic events and postpartum hemorrhage. Monitoring coagulation changes is essential to ensure maternal and fetal health. Thromboelastography (TEG), which provides a detailed assessment of the coagulation cascade, remains underutilized across all stages of pregnancy. Methods: This retrospective study included 92 pregnant women grouped by trimester (30 in the first, 34 in the second, and 28 in the third), and 30 non-pregnant women as controls. Standard coagulation metrics [Prothrombin Time (PT), activated Partial Thromboplastin Time (APTT), Thrombin Time (TT) and Fibrinogen (FIB)] and TEG parameters (R, K, α-angle, MA) were measured and compared. Results: As pregnancy progressed, PT, APTT, and TT decreased, while Fibrinogen levels increased significantly compared to the control group (P<0.05). TEG results showed a decrease in R and K values, with an increase in α-angle and MA across trimesters (P<0.05). ROC analysis showed that combining TEG with traditional tests improved the accuracy of assessing coagulation status, yielding an AUC of 0.876, sensitivity of 84.0%, and specificity of 83.6%. Conclusion: Significant changes in both TEG and traditional coagulation parameters throughout pregnancy reflect the development of a hypercoagulable state. The integration of TEG with standard tests offers a comprehensive approach for detecting coagulation abnormalities early, improving perinatal outcomes. These findings are descriptive of physiological adaptation and do not support routine TEG screening in healthy pregnancies.
Keywords: Coagulation function, Perinatal outcomes, Pregnancy, Thromboelastogram, Trimesters
Received: 24 Sep 2025; Accepted: 28 Nov 2025.
Copyright: © 2025 Li, Zhu, Chen, Wang and Sha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ying Sha
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