ORIGINAL RESEARCH article
Front. Med.
Sec. Family Medicine and Primary Care
Does joint mobilization effectively improve chronic ankle instability ? A Systematic Review and Meta-analysis
Provisionally accepted
Qimei JiangXiaoping Zhou
Rubing YanChuansheng HongPeng TangShaopeng WuHongbing LiXiaoyu Wu
Qinghua Luo*- Southwest Hospital, Chongqing, China
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Objective: The aim of this study is to systematically evaluate the effectiveness of joint mobilization (JM) in improving chronic ankle instability(CAI). Methods: We conducted a search in six databases—PubMed, Embase, Cochrane Library, Web of Science, Pedro, and China National Knowledge Infrastructure (CNKI)—up to March 10, 2025. We included all published randomized controlled trials (RCTs) on JM for the treatment of CAI. The primary outcome measure was ankle function (Cumberland Ankle Instability Tool, CAIT), and the secondary outcomes were pain and ankle range of motion (ROM). All outcome measures were analyzed by calculating standardized mean differences (SMDs) and 95% confidence intervals (CIs). Results: We identified 237 studies across six databases and ultimately included 8 RCTs involving 318 subjects with CAI. Our findings indicate that, compared to the control group, JM effectively improves ankle function (SMD = 1.62; 95% CI = 0.29 to 2.94; P = 0.02, I² = 92%) and ROM (SMD = 1.18; 95% CI = 0.22 to 2.15; P < 0.0001, I² = 90%) in CAI subjects, but no significant difference was observed in ankle pain (SMD = -0.27; 95% CI = -0.68 to 0.13; P = 0.18, I² = 0%). Conclusion: JM has been shown to effectively improve ankle joint function and ROM in subjects with CAI, although it does not significantly alleviate pain associated with CAI.
Keywords: Joint mobilization, Chronic ankle instability, Systematic review, Meta-analysis, randomized controlled trials
Received: 24 Sep 2025; Accepted: 17 Nov 2025.
Copyright: © 2025 Jiang, Zhou, Yan, Hong, Tang, Wu, Li, Wu and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qinghua Luo, lqh1987@tmmu.edu.cn
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