BRIEF RESEARCH REPORT article
Front. Med.
Sec. Translational Medicine
Optimization of Concentration-Directed Blood Purification Therapy in the Management of Diquat Poisoning
Provisionally accepted
- 1Emergency Department, Shangjinnanfu Hospital, West China Hospital, Sichuan University, Chengdu, China
- 2Emergency Department, West China Hospital, Sichuan University, Chengdu, China
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Diquat, a non-selective herbicide extensively used in China, is characterized by moderate toxicity and the absence of a specific antidote. Acute diquat poisoning frequently leads to multiple organ dysfunction syndrome (MODS), posing significant clinical challenges. This study investigated the application and optimization of concentration-directed blood purification therapy in patients suffering from diquat poisoning complicated by MODS. We analyzed the clinical outcomes of four patients who underwent hemodialysis, hemoperfusion (HP), and other blood purification modalities. The results demonstrated that individualized treatment regimens—guided by real-time monitoring of plasma diquat concentrations—markedly enhanced therapeutic efficacy and improved patient prognoses. By dynamically tailoring blood purification protocols to the patients' toxin levels, this study introduced a novel clinical intervention strategy for the management of acute diquat poisoning. These findings underscore the clinical value of concentration-guided blood purification therapy and offer important insights for its broader implementation in practice.
Keywords: Diquat, acute diquat poisoning, optimization of concentration-directed, bloodpurification therapy, case series
Received: 26 Sep 2025; Accepted: 05 Nov 2025.
Copyright: © 2025 Qian, Xie, Liu, He and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu Cao, caoyu@wchscu.cn
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