Editorial: Case Reports in Tumor Genomics and ctDNA in Precision Medicine

Li Chen¹Alice Chen^2*

• ¹National Cancer Institute Frederick National Laboratory for Cancer Research, Frederick, United States
• ²AP Chen Consultant, Potomac, United States

The collection of works for this Research Topic includes four case reports articles in tumor genomics or ctDNA in precision medicine, covering different type of variants on different cancer histologies. Xiong and Xia reported one case with ALK-positive mutations lung adenocarcinoma in which the patient achieved a prolonged progression-free survival after undergoing precise pleural effusion NGS and receiving combined bevacizumab treatment following multiple-line ALK-TKI resistance. Chang et al. identified a novel missense mutation in SRRM2 through whole exome sequencing and Sanger sequencing in a patient who exhibited similar characteristics of previously reported cases of SRRM2-associated neurodevelopmental disorders, which expanded spectrum of known mutations in SRRM2. Jin et al. discussed a rare case of an intracranial tumor with CIC-NUTM1 fusion and provided literature review for such cases. Finally, Troullioud et al. reported a first case of Wilms tumor in an individual with Dias-Logan syndrome, in which a de novo likely pathogenic germline variant of BCL11A was detected.The case reports in this Research Topic catalogue these variants and their potential impact on the patient treatment. It will benefit clinicians to optimize patient care and facilitate precision oncology approaches that target specific genetic alterations for improved outcomes in cancer patients. In conclusion, we thank all authors who contributed to the development of the articles and the reviewers for their valuable comments. We also encourage continued reporting of UVS that have clinical impact as these case reports adds to the ultimate patient care.