ORIGINAL RESEARCH article

Front. Microbiomes

Sec. Host and Microbe Associations

Volume 4 - 2025 | doi: 10.3389/frmbi.2025.1512257

This article is part of the Research TopicDefining a Healthy MicrobiomeView all 5 articles

Categorizing and Characterizing Intestinal Dysbiosis: Evaluating Stool Microbial Test Clinical Utility

Provisionally accepted
Lia OliverLia Oliver1*Sara Ramió-PujolSara Ramió-Pujol1Marta MalagónMarta Malagón1Mireia Sánchez-VizcainoMireia Sánchez-Vizcaino1Roser Sánchez- AlgansRoser Sánchez- Algans1Eva LacostaEva Lacosta1Marc SaezMarc Saez2Mariona Serra-PagèsMariona Serra-Pagès1Xavier AldeguerXavier Aldeguer1,3Jesus Garcia-GilJesus Garcia-Gil1,4Sara OduberSara Oduber3
  • 1GoodGut S.L., Girona, Spain
  • 2Research Group on Statistics, Econometrics and Health (GRECS) of University of Girona, Girona, Spain
  • 3Bofill Clinic, Girona, Catalonia, Spain
  • 4Department of Biology, Faculty of Sciences, University of Girona, Girona, Catalonia, Spain

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Background: Interest in the intestinal microbiota has surged in recent years, leading to the development of various microbiota tests utilizing stool analysis. This study aimed to assess the clinical utility of the TestUrGut. Results: The abundances of different microbial markers analysed correlated with various factors and symptoms. While no age differences were observed, an increase in A. muciniphila abundance was noted in women compared to men. Body mass index significantly influenced the abundance of A. muciniphila and M. smithii. Additionally, variations in the abundances of A. muciniphila and M. smithii, as well as a greater presence of Firmicutes or Bacteroidetes based on stool patterns, were linked to diarrhoea or constipation. The dysbiosis index was validated, distinguishing between temporary and pathological dysbiosis. Conclusions: This study revealed significant relationships between the intestinal microbiota and digestive tract symptoms. Microbial markers have emerged as robust indicators of the overall state of the intestinal microbiota, demonstrating that variations are closely associated with patients' clinical symptoms.

Keywords: Gut Microbiota, Dysbiosis, clinical utility, Stool test, Healthy microbiome

Received: 16 Oct 2024; Accepted: 22 Apr 2025.

Copyright: © 2025 Oliver, Ramió-Pujol, Malagón, Sánchez-Vizcaino, Sánchez- Algans, Lacosta, Saez, Serra-Pagès, Aldeguer, Garcia-Gil and Oduber. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Lia Oliver, GoodGut S.L., Girona, Spain

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material