ORIGINAL RESEARCH article
Front. Mol. Neurosci.
Sec. Molecular Signalling and Pathways
Volume 18 - 2025 | doi: 10.3389/fnmol.2025.1613702
Exploring Research Trends and Hotspots in PI3K/Akt Signaling Pathway in Ischaemic Stroke: A Bibliometric Analysis
Provisionally accepted
- 1The First Clinical College of Anhui University of Chinese Medicine, Hefei, Anhui Province, China
- 2Graduate School, Anhui University of Chinese Medicine, Hefei, Anhui Province, China
- 3Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
AbstractObjective: This study explores potential therapeutic strategies by determining the current research status, hotspots, and development trends through bibliometric analysis of the PI3K/Akt in ischemic stroke (IS).Methods: We searched the Web of Science Core Collection for publications on IS and the PI3K/Akt pathway, covering January 1, 2010, to December 31, 2024. VOSviewer and CiteSpace software were used to analyze research hotspots and cutting-edge topics in the field and generate visual maps of relevant countries, organizations, authors, journals, keywords, and references. Results: A total of 635 publications were analyzed. The number of publications indicates a steady annual increase in research output. China, Capital Medical University, and Wang Lei were identified as the most prolific country, institution, and author, respectively. The top three contributing journals were Brain Research, Journal of Ethnopharmacology, and Frontiers in Pharmacology. Autophagy, microglia and neuroinflammation, bioinformatics approaches, and traditional Chinese medicine (TCM) are not only current research areas but also important trends for future research. Notably, targeting IS with TCM holds significant potential for translating basic research findings into clinical applications.Conclusion: This bibliometric analysis provides an in-depth overview of research on the PI3K/Akt pathway in IS, revealing current research status, hotspots, and future research trends. This will provide valuable guidance and direction for developing novel therapeutic strategies targeting this pathway.
Keywords: PI3K/AKT, Signaling Pathways, bibliometric analysis, ischemic stroke, visual analysis, Scientific networks
Received: 17 Apr 2025; Accepted: 02 Jun 2025.
Copyright: © 2025 Liu, Ye, Bai, Dai, Su, Hu and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Peijia Hu, Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, 230061, Anhui Province, China
Hongliang Cheng, Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, 230061, Anhui Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.