REVIEW article
Front. Mol. Neurosci.
Sec. Molecular Signalling and Pathways
Volume 18 - 2025 | doi: 10.3389/fnmol.2025.1626640
TRP channels in mammalian hearing loss
Provisionally accepted
Zhidong Zhang1,2
baoshan wang1*- 1Department of Otolaryngology-Head and Neck Surgery,The Second Hospital of Hebei Medical University, Shijiazhuang, China, Shijiazhuang, China
- 2Department of Otolaryngology-Head and Neck Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China, shijiazhuahng, China
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Hearing loss, a common sensory disorder, significantly diminishes quality of life and can stem from diverse causes, including genetic predispositions, aging, noise exposure, and ototoxic medications. Recent research has highlighted the involvement of transient receptor potential (TRP) channels in auditory function and hearing loss. This review offers a comprehensive overview of the current knowledge regarding the roles of TRP channels in mammalian auditory function and hearing loss. By synthesizing the latest research findings, this review aims to elucidate the complex interplay between TRP channels and auditory function, emphasizing their significance in the pathogenesis of hearing loss and identifying potential targets for future therapeutic interventions.
Keywords: TRP channels, Hearing Loss, Cochlea, sensory transduction, therapeutic targets
Received: 11 May 2025; Accepted: 12 Jun 2025.
Copyright: © 2025 Zhang and wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: baoshan wang, Department of Otolaryngology-Head and Neck Surgery,The Second Hospital of Hebei Medical University, Shijiazhuang, China, Shijiazhuang, China
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