REVIEW article
Front. Mol. Neurosci.
Sec. Brain Disease Mechanisms
Dynamic Glycosylation Remodeling in Neurological Disorders
Provisionally accepted
- 1Tianjin Medical University, Tianjin, China
- 2Tianjin University of Traditional Chinese Medicine, Tianjin, China
- 3Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin, China
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Glycosylation, a crucial post-translational modification, involves the covalent attachment of monosaccharides or oligosaccharides to proteins. This process significantly influences protein stability and function. Within the nervous system, glycosylation regulates key processes including neuronal differentiation, migration, synapse formation, and neurotransmitter release and signaling. Its proper functioning is essential for maintaining neuronal homeostasis and reducing the risk of neurological disorders. Understanding the specific mechanisms by which glycosylation impacts the central nervous system is therefore essential for developing novel therapeutic strategies. This review focuses on the roles of three major glycosylation types—N-glycosylation, O-glycosylation, and O-GlcNAcylation—in the pathogenesis of central nervous system disorders.
Keywords: Glycosylation, O-GlcNAcylation, neurodegeneration, Psychiatry, Alzheimer's disease
Received: 28 Jul 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Xing, Gong, Xia, Tu, Yuan, Yin and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yiqing Yin, yinyiqing@tmu.edu.cn
Kaiyuan Wang, kywang@tmu.edu.cn
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