MINI REVIEW article
Front. Nat. Prod.
Sec. Natural Product Biosynthesis
Volume 4 - 2025 | doi: 10.3389/fntpr.2025.1616031
This article is part of the Research TopicFrontiers in Natural Products: Review CollectionView all 3 articles
Recent advancement of cyanobactins and cyanobactin prenyltransferases from 2021 to 2024
Provisionally accepted
- Latvian Institute of Organic Synthesis, Riga, Latvia
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Macrocyclic compounds have emerged in the 21 st century, among which cyclic peptides are of particular interest. Cyanobactins are ribosomally synthesized and post-translationally modified peptides (RiPPs), many of which exist as cyclic peptides with a prenyl moiety, and prenylation can improve their structural stability and biological activity. This mini-review highlights the recently discovered cyanobactins and cyanobactin prenyltransferases from 2021 to 2024. Cyanobactin prenyltransferases will allow access to unique prenylated natural products for applications in drug discovery.
Keywords: Cyanobacterial natural products, cyanobactins, RiPPs, post-translational modification, Prenyltransferases
Received: 22 Apr 2025; Accepted: 26 May 2025.
Copyright: © 2025 Habib Khan and Phan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chin-Soon Phan, Latvian Institute of Organic Synthesis, Riga, Latvia
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