ORIGINAL RESEARCH article
Front. Nat. Prod.
Sec. Biological Activities of Natural Products
Volume 4 - 2025 | doi: 10.3389/fntpr.2025.1689287
This article is part of the Research TopicPlant-Derived Bioactives in Disease Modulation: Bridging Molecular Mechanisms and Therapeutic ApplicationsView all articles
Evaluation of Anti-Diabetic Potency of Tinospora cordifolia Stem against Streptozotocin and High-Fat Diet-Induced Diabetic rats
Provisionally accepted
- 1Assam Agricultural University Faculty of Home Science, Jorhat, India
- 2Assam Agricultural University College of Veterinary Science, Khanapara, India
- 3Assam Agricultural University Faculty of Agriculture, Jorhat, India
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In the Indian Ayurvedic system, Tinospora cordifolia is highly prized for its distinct phytochemical components. While the sun-dried portions of this herb are less examined, the shade-dried stem has been thoroughly investigated for its potential to prevent diabetes. Hence present study aimed to assess anti-diabetic efficacy of the sundried stem of T. cordifolia using a Streptozotocin (STZ) and High Fat Diet (HFD) induced diabetic rat model. The GC-MS (Gas Chromatography-Mass Spectrometry) analysis revealed that anti-diabetic components like Octacosanol, Oleic acid, and Palmitoleic acid were present in its methanolic extract. The in-vivo investigation showed that the induction of diabetes evoked some physical alterations, such as weight loss and reduction in gonad size, in male Wistar rats, which were improved after supplementation with T. cordifolia. The 900mg/kg wt dose showed the strongest Fasting Blood Glucose (FBG) lowering capacity (71%), whereas triglyceride (<60 mg/dl) and total cholesterol (<80 mg/dl) were significantly lowered in treated groups compared to the controls. Though FBG levels were lowered in the treatment groups, the serum insulin levels (26.09pg/ml) didn't show any elevation in values. Simultaneously, Leptin hormone was improved along with serum vitamin D levels, and no improvement or major changes in pancreatic tissues were found. This study is the first to report that Tinospora cordifolia extract can increase serum vitamin D level in diabetic rats and may have a role in vitamin D regulation.
Keywords: Tinospora cordifolia, GC-MS, phytochemicals, Type-II diabetes, Gonad size
Received: 20 Aug 2025; Accepted: 21 Oct 2025.
Copyright: © 2025 MAHAPATRA, Beniwal, Sarma, Shome, Goswami and Das. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mamoni Das, correspondingmdas@gmail.com
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