ORIGINAL RESEARCH article
Front. Nat. Prod.
Sec. Isolation and Purification
This article is part of the Research TopicInnovative Approaches in Isolation and Purification: Balancing Efficiency and SustainabilityView all 5 articles
Network Pharmacology-Based Strategy and Phytochemical Screening of Antioxidants Suggesting the Potential Anti-obesity Relevance of Soybean Food Bars
Provisionally accepted
- 1Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin, Banjarmasin, Indonesia
- 2Bhayangkara Hospital, Banjarmasin, Indonesia
- 3Universitas Gadjah Mada, Yogyakarta, Indonesia
- 4Guangzhou HC Pharmaceutical Co., Ltd, Guangzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Functional food products are widely available in the market and have several benefits, such as high protein and low calorie content, for addressing obesity. However, the regulation of product content, which results in weight maintenance, needs to be described. This study aimed to explore methods to assess the influence of anti-obesity food bars made from soybeans on antioxidants in functional food products that are widely available in the market. These methods include network pharmacology screening, bioactive gene analysis, interaction network development, phytochemical screening, molecular docking, and antioxidant activity testing. Screening revealed that the main bioactivities of the soybean food bars were glycitein and 6"-O-malonylglycitin, which have a high affinity for molecular docking. The food bar methanol and ethanol extracts had higher ES50 values (1.30 and 2.00 mg/mL, respectively) than genistein (0.13 mg/mL), indicating weak antioxidant activity. Therefore, the ethanol and methanol extracts of the soybean food bar exhibited weak antioxidant activity. This study suggests that soybean-based food bars may have potential anti-obesity relevance through predicted interactions with leptin signaling proteins, network pharmacology analysis, and measurable antioxidant activity.
Keywords: Computational pharmacy, Comorbidity, Flavonoids, Obesity, Oxidative Stress, soy, metabolic syndrome, weight management
Received: 29 Aug 2025; Accepted: 24 Oct 2025.
Copyright: © 2025 Rustandi, Hayati, Nugroho, Amalia, Nastasya and Mahal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Tedi Rustandi, tedirustandi26@gmail.com
Fakhriah Hayati, fakhriahhayati@gmail.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.