ORIGINAL RESEARCH article
Front. Ophthalmol.
Sec. Cornea and Refractive Surgery
Volume 5 - 2025 | doi: 10.3389/fopht.2025.1577836
This article is part of the Research TopicOcular Surface Disorders- An InsightView all 4 articles
To assess the effectiveness of Systane COMPLETE in improving Meibomian Gland
Provisionally accepted
Namrata Sharma1,2*
AAFREEN BARI1,2
Anu Malik1,2Prafulla Kumar Maharana1,2Chetan Shakkarwal1,2
Shivam Sharma1,2Aishwarya Dasgupta1,2- 1Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
- 2All India Institute of Medical Sciences, New Delhi, National Capital Territory of Delhi, India
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Purpose: To assess the effectiveness of Systane COMPLETE in reducing symptoms of ocular dryness and in improving MG Score in subjects with mild-moderate dry eye.Methods: A prospective, interventional, single-centre single arm study was done including cases of mild to moderate dry eye disease (DED). The cases were advised topical lipid-based combination of propylene glycol (PG) and hydroxypropyl guar (HPG) (Systane® COMPLETE) four times a day for 30 days. The dry eye assessment parameters, Meibo score and ocular surface disease index (OSDI) questionnaire was obtained pre and post-usage.Results: A total of 105 cases with mild-to-moderate dry eye disease were included in the study.There was an improvement in tear break up time (TBUT) (p<0.0001), Schirmer's test (p<0.0001), lipid layer thickness (LLT) (p<0.0001), tear meniscus height (TMH) (p=0.0002), non-invasive break up time (NIBUT) (p<0.0001), OSDI (p<0.0001), upper lid meibomian gland score (p=0.02), corneal staining score (p<0.0001) and Meibo sore (p=0.19).Lipid based nano emulsion of PG-HPG helps in improving the objective parameters and symptoms of dry eye disease. Additionally, it improves the meibomian gland health.
Keywords: Dry eye disease (DED), Systane complete, tear break up time (TBUT), Schirmer, Meibo Score
Received: 16 Feb 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 Sharma, BARI, Malik, Maharana, Shakkarwal, Sharma and Dasgupta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Namrata Sharma, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.