CASE REPORT article
Front. Ophthalmol.
Sec. Glaucoma
Volume 5 - 2025 | doi: 10.3389/fopht.2025.1658649
Recurrent Intraocular Pressure Elevation During Hemodialysis In A Patient With Pseudoexfoliation Glaucoma
Provisionally accepted
- The Ottawa Hospital, Ottawa, Canada
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Introduction: Intraocular pressure (IOP) elevation during dialysis has been observed in patients with glaucoma. This is thought to result from rapid shifts in plasma osmolality, leading to fluid movement into the anterior chamber, a phenomenon referred to as ocular dialysis disequilibrium. This case highlights a patient with advanced pseudoexfoliation glaucoma who developed recurrent, symptomatic IOP spikes during dialysis, posing management challenges. Methods: Case report. Results: A 65-year-old male with advanced pseudoexfoliation glaucoma experienced recurrent left eye pain and vision loss during hemodialysis, with IOP spikes up to mid 50s (mmHg), requiring early dialysis termination. Medical management including topical drops, oral acetazolamide, and dialysis modifications failed to adequately control IOP. The patient later underwent Ahmed glaucoma valve implantation which stabilized IOP (8– 13 mmHg), eliminated dialysis-related pain, and allowed return to standard dialysis sessions. At 6 months, visual acuity was 20/80+2 OS with IOP well controlled on topical therapy. Conclusion: This case demonstrates that ocular dialysis disequilibrium can cause symptomatic IOP spikes in glaucoma patients and may be unresponsive to medical therapy alone. Surgical intervention may be necessary for long-term IOP control. Early recognition and interdisciplinary coordination between ophthalmology and nephrology is critical to prevent irreversible vision loss.
Keywords: Glaucoma, hemodialysis, Intraocular Pressure, Ocular dialysis disequilibrium, Pseudoexfoliation
Received: 02 Jul 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 Herman, Kanda, Podury and Jegatheswaran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Pushpinder Kanda, pkand042@uottawa.ca
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