Discovery Stories of RET Fusions in Lung Cancer: A Mini-Review

Abstract

In 2004, a chemical inhibitor of the kinase activity of EGFR was reported to be effective in a subset of lung cancer patients with activating somatic mutations of EGFR. It remained unclear, however, whether kinase fusion genes also play a major role in the pathogenesis of lung cancers. The discovery of the EML4-ALK fusion kinase in 2007 was a breakthrough for this situation, and kinase fusion genes now form a group of relevant targetable oncogenes in lung cancer. In this mini-review article, the discovery of REarrangement during Transfection fusions, the third kinase fusion gene in lung cancer, is briefly described.

Introduction

Somatic mutations cause cancer via multiple mechanisms, including point mutations, insertions, deletions, and gene rearrangements. In non-small cell lung cancer (NSCLC), one of the most common causes of cancer-related deaths, these oncogenic mutations are usually mutually exclusive, and generally only a single major driver mutation is found in each case. In addition, such a cancer usually depends on the signal pathway stimulated by the principal oncogene for its survival (oncogene addiction) (Weinstein, 2002). In 2004, it was reported that a chemical inhibitor of the kinase activity of EGFR was effective in a subset of lung cancer patients with activating somatic mutations of EGFR (Lynch et al., 2004; Paez et al., 2004). NSCLC in which EGFR inhibitors are effective preferentially develop in Asian and non-smoker populations, generally lacking other targetable driver mutations (Paez et al., 2004; Pao et al., 2004; Shigematsu et al., 2005). In addition to EGFR mutations, kinase fusion genes have become a group of relevant oncogenes in NSCLC, because targeted inhibition of oncogenic kinase fusion proteins also leads to growth inhibition of the cancer cells and regression of the patient’s tumor.

Gene fusion was known to be a major mechanism of oncogenesis in hematopoietic neoplasms and sarcomas (Mitelman, 2000). Various types of fusion oncogenes were reported (Mitelman et al., 2007) after the identification of the BCR-ABL1 fusion kinase in chronic myelogenous leukemia (Bartram et al., 1983). In contrast, it remained unclear for a long time whether such fusion oncogenes also play a major role in the pathogenesis of epithelial tumors. The discovery of the EML4-ALK fusion kinase in NSCLC via inv(2)(p21p23) was a breakthrough in this scenario (Soda et al., 2007). Moreover, several small molecules, such as crizotinib (Kwak et al., 2010; Shaw et al., 2013) and alectinib (Seto et al., 2013; Takeuchi et al., 2016; Hida et al., 2017), showed improved survival outcomes in ALK fusion-positive NSCLC patients. These clinical successes suggested that targeting specific fusion kinases was a promising strategy also for treating carcinomas (epithelial cancers). Representative fusions in epithelial tumors are listed in Table 1.

Receptor tyrosine kinases including ALK usually comprise an extracellular receptor domain, a transmembrane domain, and an intracytoplasmic tyrosine kinase domain. The receptor domain binds to ligands, resulting in dimerization of the kinase protein. Then, the dimerized proteins are autophosphorylated and stimulate the RAS-MAPK-ERK and PI3K-AKT pathways to promote cell proliferation, migration, and differentiation. A receptor tyrosine kinase gene rearrangement gives rise to the expression of the fusion kinase protein if the 5′-partner gene fuses with the 3′-kinase gene in an in-frame fashion. These fusion kinases can be oncogenic when they retain the kinase domain and are dimerized through the 5′ partner, because this dimerization mimics that of the wild-type receptor tyrosine kinases through ligand binding. Consequently, a fusion kinase is constitutively expressed, dimerized, and autoactivated, and its downstream signaling promotes cell proliferation and survival.

Alk Fusion

ALK is a receptor tyrosine kinase that is not expressed in normal cells in adult mammals except for nerve cells. The most common mechanism of ALK overexpression and ALK kinase domain activation in neoplastic cells is the formation of a fusion protein with a partner through genomic rearrangement. In fact, ALK was first discovered in anaplastic large cell lymphoma (ALCL) in the form of a fusion protein, NPM1-ALK (Morris et al., 1994; Shiota et al., 1994). Other ALK fusion partners reported in ALCL are TFG, TPM3, TPM4, ATIC, RNF213, CLTC, MSN, MYH9, and TRAF (Hernandez et al., 1999; Lamant et al., 1999, 2003; Colleoni et al., 2000; Touriol et al., 2000; Meech et al., 2001; Tort et al., 2001; Cools et al., 2002; Feldman et al., 2013). NPM1-ALK is the most common ALK fusion in ALK-positive ALCL (70–80%), followed by TPM3-ALK (12–18%) (Tsuyama et al., 2017), and other fusions are rare. Except for ALCL, several hematopoietic neoplasms have been reported to have the following ALK fusion partners: CLTC, NPM1, SEC31A, SQSTM1, RANBP2, and EML4 in ALK-positive large B-cell lymphoma (Gascoyne et al., 2003; Van Roosbroeck et al., 2010; Takeuchi et al., 2011; Lee et al., 2014; Sakamoto et al., 2016); TPM3 in ALK-positive histiocytosis (Chan et al., 2008); and RANBP2 in myeloid leukemia (Maesako et al., 2014). In solid tumors, ALK fusions were identified in approximately 50% of inflammatory myofibroblastic tumor with the following fusion partners: TPM3, TPM4, CLTC, ATIC, CARS, SEC31A, RANBP2, PPFIBP1, FN1, TFG, EML4, LMNA, PRKAR1A, DCTN1, and RRBP1 (Lawrence et al., 2000; Bridge et al., 2001; Cools et al., 2002; Debelenko et al., 2003; Debiec-Rychter et al., 2003; Ma et al., 2003; Panagopoulos et al., 2006; Takeuchi et al., 2011; Lovly et al., 2014; Lee J.C. et al., 2017). Other ALK fusion-positive solid tumors include renal cancer (Debelenko et al., 2011; Marino-Enriquez et al., 2011; Sugawara et al., 2012; Kusano et al., 2016), colon cancer (Lin et al., 2009; Lipson et al., 2012; Stransky et al., 2014; Lee et al., 2015; Yakirevich et al., 2016), breast cancer (Lin et al., 2009), ovarian cancer (Ren et al., 2012), thyroid cancer (Cancer Genome Atlas Research Network, 2014; Kelly et al., 2014; McFadden et al., 2014; Perot et al., 2014; Stransky et al., 2014; Ji et al., 2015), and bladder cancer (Stransky et al., 2014). The frequencies are 1–2% in thyroid cancer (Cancer Genome Atlas Research Network, 2014; Kelly et al., 2014; McFadden et al., 2014; Ji et al., 2015) and less than 1% in kidney and colon cancers (Sugawara et al., 2012; Yakirevich et al., 2016). In NSCLC, EML4 is the most common partner of ALK. Although very rare, KIF5B, KLC1, TFG, STRN, PTPN3, HIP1, TPR, SEC31A, SQSTM1, DCTN1, and CRIM1 were also reported as an ALK fusion partner (Rikova et al., 2007; Takeuchi et al., 2009; Jung et al., 2012; Togashi et al., 2012; Majewski et al., 2013; Choi et al., 2014; Hong et al., 2014; Iyevleva et al., 2015; Kim et al., 2016; Tan et al., 2016).

Ret Fusion

REarrangement during Transfection (RET) was identified by Takahashi et al. in 1985 as a proto-oncogene that underwent rearrangement during the transfection of DNA extracted from human T-cell lymphoma into NIH-3T3 cells (Takahashi et al., 1985). RET is a receptor tyrosine kinase encoded by a gene located on 10q11.22 (Ishizaka et al., 1989), and physiologically plays an important role in the development of neurons and kidneys. The first RET fusion in human cancer samples, CCDC6-RET, was identified in papillary thyroid carcinoma by Grieco et al. (1990). RET fusions are detected in 13–43% of papillary thyroid carcinomas (Kondo et al., 2006), and at least 12 RET fusions have been reported so far (Table 2).

Discovery of Ret Fusions in Lung Cancer

In 2012, the first RET fusion in lung cancer, KIF5B-RET, was reported independently by 4 groups from Korea (Ju et al., 2012), Japan (2 groups) (Kohno et al., 2012; Takeuchi et al., 2012), and the United States (Lipson et al., 2012). Ju et al. (2012) examined tissue and peripheral blood samples from a 33-year-old Korean never-smoking male with lung adenocarcinoma. The patient was negative for EGFR and KRAS mutations, and the EML4-ALK fusion gene, which were the three well-known driver mutations in lung adenocarcinoma at that time. Fifty-two fusion transcripts were called by transcriptome analysis in the patient’s adenocarcinoma. Out of 52 fusions, they could detect a corresponding genomic rearrangement only for KIF5B-RET fusion (KIF5B exon 16;RET exon 12 fusion variant. K16;R12) by whole genome sequencing. Additionally, they performed transcriptome analysis in 5 lung adenocarcinomas that were negative for EGFR and KRAS mutations and EML4-ALK, and identified one more case with KIF5B-RET fusion transcript (K15;R12). Furthermore, they found another KIF5B-RET-positive case (K23;R12) in 15 “double-negative (negative for EGFR mutation and EML4-ALK but KRAS status unknown)” lung adenocarcinomas by RT-PCR. Based on their detection rate, they estimated that the fusion might exist in approximately 6% of lung adenocarcinomas.

The following three studies were published in the same issue of the same journal, reflecting the “fusion kinase discovery race in major carcinomas” in those days. In the three studies, the frequency and oncogenicity of KIF5B-RET were more specifically evidenced, and growth inhibition analyses using cell lines and RET inhibitors were performed. Kohno et al. (2012) at the National Cancer Center researchers in Japan performed whole-transcriptome sequencing of 30 lung adenocarcinomas to identify new fusion genes that could be targeted for therapy. As a result, they discovered a KIF5B-RET fusion transcript in 1 out of 30 cases. In addition, 289 Japanese lung adenocarcinomas were screened by RT-PCR and Sanger sequence analyses, and the KIF5B-RET fusion gene was identified in 5 cases. In total, they identified 6 KIF5B-RET-positive cases out of 319 lung adenocarcinomas (1.9%), and 4 fusion variants in these 6 tumors. They also examined lung adenocarcinomas in the United States and Norway, and detected a KIF5B-RET transcript in one of the 80 (1.3%) subjects from the United States, but not in the 34 from Norway. They exogenously expressed a KIF5B-RET transcript (KIF5B exon 15;RET exon 12 variant. K15;R12) in the H1299 human lung cancer cell line and showed that Tyr905 was phosphorylated in the absence of serum stimulation. This phosphorylation was suppressed by vandetanib, a tyrosine kinase inhibitor to several receptor tyrosine kinases, including RET. They also showed that expression of exogenous KIF5B-RET induced morphological transformation and anchorage-independent growth of NIH-3T3 cells, which was suppressed by vandetanib.

Lipson et al. (2012) analyzed genomic DNA extracted from 24 formalin-fixed paraffin-embedded (FFPE) specimens of NSCLC by capture sequencing targeting 2,574 coding exons of 145 cancer-relevant genes and 37 introns of 14 frequently rearranged genes in cancer. They identified a KIF5B-RET transcript (K15;R12), generated via an 11,294,741-bp pericentric inversion on chromosome 10 in a lung adenocarcinoma from a 44-year-old never-smoking man of European ancestry. They detected KIF5B-RET fusions by RT-PCR in 1 of 121 (0.8%) European-ancestry and 9 of 405 (2%) Asian subjects, all of whom were never or limited former smokers. They estimated an overall occurrence rate of 2.0% (95% CI 0.8–3.1%). Four transcript variants were reported by them: K15;R12, K16;R12, K22;R12, and K15;R11. Ba/F3 cells, which are dependent on interleukin-3 (IL-3) for growth, that expressed KIF5B-RET were transformed and lived without IL-3. The cells were sensitive to sunitinib, sorafenib, and vandetanib, which are multi-target kinase inhibitors that inhibit RET.

Unlike the above-mentioned three studies, Takeuchi et al. (2012) identified KIF5B-RET fusions without next-generation sequencing analyses, but with traditional methods. They established an integrated platform of conventional histopathology and molecular pathology to identify fusion genes in various types of cancer. They performed fluorescence in situ hybridization (FISH) with their laboratory-made probes on tissue microarrays of various types of cancers. Using lung cancer tissue microarrays containing 1,528 samples, rearrangement of KIF5B was examined by a split FISH assay to discover new fusions, because they previously identified KIF5B-ALK fusions in lung cancer (Takeuchi et al., 2009) and thus hypothesized that KIF5B might fuse to other kinases in lung cancer. Twenty-four KIF5B split FISH-positive tumors were identified; among them, a KIF5B-RET transcript (K23;R12) was identified by 3′ rapid amplification of cDNA ends (RACE). Then, 22 RET rearrangement-positive tumors were identified in 1,528 lung cancers by RET split FISH. Among the 22 cases, 12 KIF5B-RET-positive tumors were identified through a multiplex RT-PCR system that captures all possible KIF5B-RET fusions: 8 cases with K15;R12, and one case each with the K16;R12, K22;R12, K23;R12, and K24;R11. The presence of inv(10)(p11.22q11.2) was supported by a KIF5B-RET fusion FISH assay in all 12 of these tumors. In lung cancer, they also identified CCDC6-RET, which is the first RET fusion identified in thyroid cancer (Grieco et al., 1990). In a routine pathology diagnosis during the study period, a pathologist in the group encountered an adenocarcinoma with a mucinous cribriform pattern that is a histopathological marker for the presence of EML4-ALK (Inamura et al., 2008). The case was, however, negative for ALK fusion and was positive for CCDC6-RET, as determined by FISH and inverse RT-PCR. In the remaining 10 tumors, another CCDC6-RET-positive tumor was identified by RT-PCR. In total, 14 RET fusion-positive tumors (13 out of the 1,528 tumors tested, and one additional tumor found through a routine pathology diagnostic service) were identified. RET fusions existed in 0.9% (13 out of 1,482) of the NSCLCs and 1.2% (13 out of 1,119) of the adenocarcinomas. The researchers demonstrated the oncogenicity of all the 5 KIF5B-RET fusion variants they identified through a focus formation assay and a mouse subcutaneous transplantation assay using NIH-3T3 cells expressing each KIF5B-RET variant. KIF5B-RET (K15;R12) transfected Ba/F3 cells grew in the absence of IL-3. Vandetanib inhibited the proliferation of cells expressing K15;R12 but not the proliferation of cells expressing EML4-ALK.

To date, at least 15 RET fusions have been reported in NSCLC including KIF5B-RET (Ju et al., 2012; Kohno et al., 2012; Lipson et al., 2012; Takeuchi et al., 2012), CCDC6-RET (Takeuchi et al., 2012), NCOA4-RET (Wang et al., 2012), TRIM33-RET (Drilon et al., 2013), RUFY2-RET (Zheng et al., 2014), CUX1-RET (Lira et al., 2014), KIAA1468-RET (Nakaoku et al., 2014), CLIP1-RET (Drilon et al., 2016), ERC1-RET (Drilon et al., 2016), MYO5C-RET (Lee S.H. et al., 2017), EPHA5-RET (Gautschi et al., 2017), PICALM-RET (Gautschi et al., 2017), FRMD4A-RET (Velcheti et al., 2017), KIF13A-RET (Zhang et al., 2018), and WAC-RET (Velcheti et al., 2018; Table 3). Most cases of RET fusion-positive NSCLCs are adenocarcinoma, although some authors reported non-adenocarcinoma cases including adenosquamous cell carcinoma (Wang et al., 2012; Song et al., 2017) and squamous cell carcinoma (Cai et al., 2013). In RET fusion-positive adenocarcinomas, specific histological features were not identified, although several characteristic features like cytoplasmic mucin production were detected (Tsuta et al., 2014). Driver mutations in other genes including EGFR, KRAS, HER2, BRAF, ALK, and ROS1 are rare.

Concluding Remarks

REarrangement during Transfection-positive lung cancers constitute a small subset of lung adenocarcinomas showing clinicopathological features similar to those of other fusion kinase-positive lung cancers. Since their discovery, several trials for RET-positive lung cancer have been conducted using kinase inhibitors including vandetanib, cabozantinib, sorafenib, sunitinib, lenvatinib, ponatinib, and dovitinib. Although some clinical benefits were observed, efficacy was limited compared with that shown by EGFR and ALK inhibitors. The above-mentioned agents used in earlier trials are multi-kinase inhibitors, and are notably more effective to VEGFR, EGFR, and KIT than RET. Therefore, off-target dose limiting toxicity caused frequent dose reduction and discontinuation. RET inhibitors with more specificity and hence less off-target toxicity are currently undergoing clinical and preclinical development.

References

• 1

  BartramC. R.de KleinA.HagemeijerA.van AgthovenT.Geurts van KesselA.BootsmaD.et al (1983). Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.Nature306277–280. 10.1038/306277a0

  • CrossRef
  • Google Scholar
  • View reference in article

• 2

  BongarzoneI.ButtiM. G.CoronelliS.BorrelloM. G.SantoroM.MondelliniP.et al (1994). Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas.Cancer Res.542979–2985.

  • Pubmed Abstract
  • Google Scholar
  • View reference in article

• 3

  BongarzoneI.MonziniN.BorrelloM. G.CarcanoC.FerraresiG.ArighiE.et al (1993). Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A.Mol. Cell Biol.13358–366.

  • Pubmed Abstract
  • Google Scholar
  • View reference in article

• 4

  BridgeJ. A.KanamoriM.MaZ.PickeringD.HillD. A.LydiattW.et al (2001). Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor.Am. J. Pathol.159411–415. 10.1016/S0002-9440(10)61711-7

  • CrossRef
  • Google Scholar
  • View reference in article

• 5

  CaiW.SuC.LiX.FanL.ZhengL.FeiK.et al (2013). KIF5B-RET fusions in Chinese patients with non-small cell lung cancer.Cancer1191486–1494. 10.1002/cncr.27940

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 6

  Cancer Genome Atlas Research Network (2014). Integrated genomic characterization of papillary thyroid carcinoma.Cell159676–690. 10.1016/j.cell.2014.09.050

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 7

  ChanJ. K.LamantL.AlgarE.DelsolG.TsangW. Y.LeeK. C.et al (2008). ALK+ histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy.Blood1122965–2968. 10.1182/blood-2008-03-147017

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 8

  ChoiY. L.LiraM. E.HongM.KimR. N.ChoiS. J.SongJ. Y.et al (2014). A novel fusion of TPR and ALK in lung adenocarcinoma.J. Thorac. Oncol.9563–566. 10.1097/JTO.0000000000000093

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 9

  CiampiR.GiordanoT. J.Wikenheiser-BrokampK.KoenigR. J.NikiforovY. E. (2007). HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma.Endocr. Relat. Cancer14445–452. 10.1677/ERC-07-0039

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 10

  ColleoniG. W.BridgeJ. A.GaricocheaB.LiuJ.FilippaD. A.LadanyiM. (2000). ATIC-ALK: a novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).Am. J. Pathol.156781–789. 10.1016/S0002-9440(10)64945-0

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 11

  CoolsJ.WlodarskaI.SomersR.MentensN.PedeutourF.MaesB.et al (2002). Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.Genes Chromosomes Cancer34354–362. 10.1002/gcc.10033

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 12

  CorviR.BergerN.BalczonR.RomeoG. (2000). RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma.Oncogene194236–4242. 10.1038/sj.onc.1203772

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 13

  DebelenkoL. V.ArthurD. C.PackS. D.HelmanL. J.SchrumpD. S.TsokosM. (2003). Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor.Lab. Invest.831255–1265. 10.1097/01.LAB.0000088856.49388.EA

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 14

  DebelenkoL. V.RaimondiS. C.DawN.ShivakumarB. R.HuangD.NelsonM.et al (2011). Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum.Mod. Pathol.24430–442. 10.1038/modpathol.2010.213

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 15

  Debiec-RychterM.MarynenP.HagemeijerA.PauwelsP. (2003). ALK-ATIC fusion in urinary bladder inflammatory myofibroblastic tumor.Genes Chromosomes Cancer38187–190. 10.1002/gcc.10267

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 16

  DrilonA.RekhtmanN.ArcilaM.WangL.NiA.AlbanoM.et al (2016). Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial.Lancet Oncol.171653–1660. 10.1016/S1470-2045(16)30562-9

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 17

  DrilonA.WangL.HasanovicA.SueharaY.LipsonD.StephensP.et al (2013). Response to Cabozantinib in patients with RET fusion-positive lung adenocarcinomas.Cancer Discov.3630–635. 10.1158/2159-8290.CD-13-0035

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 18

  FeldmanA. L.VasmatzisG.AsmannY. W.DavilaJ.MiddhaS.EckloffB. W.et al (2013). Novel TRAF1-ALK fusion identified by deep RNA sequencing of anaplastic large cell lymphoma.Genes Chromosomes Cancer521097–1102. 10.1002/gcc.22104

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 19

  GascoyneR. D.LamantL.Martin-SuberoJ. I.LestouV. S.HarrisN. L.Muller-HermelinkH. K.et al (2003). ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases.Blood1022568–2573. 10.1182/blood-2003-03-0786

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 20

  GautschiO.MiliaJ.FilleronT.WolfJ.CarboneD. P.OwenD.et al (2017). Targeting RET in patients with RET-rearranged lung cancers: results from the global, multicenter RET registry.J. Clin. Oncol.351403–1410. 10.1200/JCO.2016.70.9352

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 21

  GriecoM.SantoroM.BerlingieriM. T.MelilloR. M.DonghiR.BongarzoneI.et al (1990). PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas.Cell60557–563. 10.1016/0092-8674(90)90659-3

  • CrossRef
  • Google Scholar
  • View reference in article

• 22

  HernandezL.PinyolM.HernandezS.BeaS.PulfordK.RosenwaldA.et al (1999). TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations.Blood943265–3268.

  • Pubmed Abstract
  • Google Scholar
  • View reference in article

• 23

  HidaT.NokiharaH.KondoM.KimY. H.AzumaK.SetoT.et al (2017). Alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial.Lancet39029–39. 10.1016/S0140-6736(17)30565-2

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 24

  HongM.KimR. N.SongJ. Y.ChoiS. J.OhE.LiraM. E.et al (2014). HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma.J. Thorac. Oncol.9419–422. 10.1097/JTO.0000000000000061

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 25

  InamuraK.TakeuchiK.TogashiY.NomuraK.NinomiyaH.OkuiM.et al (2008). EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers.J. Thorac. Oncol.313–17. 10.1097/JTO.0b013e31815e8b60

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 26

  IshizakaY.ItohF.TahiraT.IkedaI.SugimuraT.TuckerJ.et al (1989). Human ret proto-oncogene mapped to chromosome 10q11.2.Oncogene41519–1521.

  • Google Scholar
  • View reference in article

• 27

  IyevlevaA. G.RaskinG. A.TiurinV. I.SokolenkoA. P.MitiushkinaN. V.AleksakhinaS. N.et al (2015). Novel ALK fusion partners in lung cancer.Cancer Lett.362116–121. 10.1016/j.canlet.2015.03.028

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 28

  JiJ. H.OhY. L.HongM.YunJ. W.LeeH. W.KimD.et al (2015). Identification of driving ALK fusion genes and genomic landscape of medullary thyroid cancer.PLoS Genet.11:e1005467. 10.1371/journal.pgen.1005467

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 29

  JuY. S.LeeW. C.ShinJ. Y.LeeS.BleazardT.WonJ. K.et al (2012). A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing.Genome Res.22436–445. 10.1101/gr.133645.111

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 30

  JungY.KimP.JungY.KeumJ.KimS. N.ChoiY. S.et al (2012). Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing.Genes Chromosomes Cancer51590–597. 10.1002/gcc.21945

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 31

  KellyL. M.BarilaG.LiuP.EvdokimovaV. N.TrivediS.PanebiancoF.et al (2014). Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer.Proc. Natl. Acad. Sci. U.S.A.1114233–4238. 10.1073/pnas.1321937111

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 32

  KimR. N.ChoiY. L.LeeM. S.LiraM. E.MaoM.MannD.et al (2016). SEC31A-ALK fusion gene in lung adenocarcinoma.Cancer Res. Treat.48398–402. 10.4143/crt.2014.254

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 33

  KohnoT.IchikawaH.TotokiY.YasudaK.HiramotoM.NammoT.et al (2012). KIF5B-RET fusions in lung adenocarcinoma.Nat. Med.18375–377. 10.1038/nm.2644

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 34

  KondoT.EzzatS.AsaS. L. (2006). Pathogenetic mechanisms in thyroid follicular-cell neoplasia.Nat. Rev. Cancer6292–306. 10.1038/nrc1836

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 35

  KlugbauerS.DemidchikE. P.LengfelderE.RabesH. M. (1998). Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5.Cancer Res.58198–203.

  • Pubmed Abstract
  • Google Scholar
  • View reference in article

• 36

  KlugbauerS.JauchA.LengfelderE.DemidchikE.RabesH. M. (2000). A novel type of RET rearrangement (PTC8) in childhood papillary thyroid carcinomas and characterization of the involved gene (RFG8).Cancer Res.607028–7032.

  • Pubmed Abstract
  • Google Scholar
  • View reference in article

• 37

  KlugbauerS.RabesH. M. (1999). The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.Oncogene184388–4393. 10.1038/sj.onc.1202824

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 38

  KusanoH.TogashiY.AkibaJ.MoriyaF.BabaK.MatsuzakiN.et al (2016). Two cases of renal cell carcinoma harboring a novel STRN-ALK fusion gene.Am. J. Surg. Pathol.40761–769. 10.1097/PAS.0000000000000610

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 39

  KwakE. L.BangY. J.CamidgeD. R.ShawA. T.SolomonB.MakiR. G.et al (2010). Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.N. Engl. J. Med.3631693–1703. 10.1056/NEJMoa1006448

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 40

  LamantL.DastugueN.PulfordK.DelsolG.MariameB. (1999). A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation.Blood933088–3095.

  • Pubmed Abstract
  • Google Scholar
  • View reference in article

• 41

  LamantL.GascoyneR. D.DuplantierM. M.ArmstrongF.RaghabA.ChhanabhaiM.et al (2003). Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma.Genes Chromosomes Cancer37427–432. 10.1002/gcc.10232

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 42

  LawrenceB.Perez-AtaydeA.HibbardM. K.RubinB. P.Dal CinP.PinkusJ. L.et al (2000). TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.Am. J. Pathol.157377–384. 10.1016/S0002-9440(10)64550-6

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 43

  LeeJ.KimH. C.HongJ. Y.WangK.KimS. Y.JangJ.et al (2015). Detection of novel and potentially actionable anaplastic lymphoma kinase (ALK) rearrangement in colorectal adenocarcinoma by immunohistochemistry screening.Oncotarget624320–24332. 10.18632/oncotarget.4462

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 44

  LeeJ. C.LiC. F.HuangH. Y.ZhuM. J.Marino-EnriquezA.LeeC. T.et al (2017). ALK oncoproteins in atypical inflammatory myofibroblastic tumours: novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma.J. Pathol.241316–323. 10.1002/path.4836

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 45

  LeeS. E.KangS. Y.TakeuchiK.KoY. H. (2014). Identification of RANBP2-ALK fusion in ALK positive diffuse large B-cell lymphoma.Hematol. Oncol.32221–224. 10.1002/hon.2125

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 46

  LeeS. H.LeeJ. K.AhnM. J.KimD. W.SunJ. M.KeamB.et al (2017). Vandetanib in pretreated patients with advanced non-small cell lung cancer-harboring RET rearrangement: a phase II clinical trial.Ann. Oncol.28292–297. 10.1093/annonc/mdw559

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 47

  LinE.LiL.GuanY.SorianoR.RiversC. S.MohanS.et al (2009). Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers.Mol. Cancer Res.71466–1476. 10.1158/1541-7786.MCR-08-0522

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 48

  LipsonD.CapellettiM.YelenskyR.OttoG.ParkerA.JaroszM.et al (2012). Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.Nat. Med.18382–384. 10.1038/nm.2673

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 49

  LiraM. E.ChoiY. L.LimS. M.DengS.HuangD.OzeckM.et al (2014). A single-tube multiplexed assay for detecting ALK, ROS1, and RET fusions in lung cancer.J. Mol. Diagn.16229–243. 10.1016/j.jmoldx.2013.11.007

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 50

  LovlyC. M.GuptaA.LipsonD.OttoG.BrennanT.ChungC. T.et al (2014). Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions.Cancer Discov.4889–895. 10.1158/2159-8290.CD-14-0377

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 51

  LynchT. J.BellD. W.SordellaR.GurubhagavatulaS.OkimotoR. A.BranniganB. W.et al (2004). Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.N. Engl. J. Med.3502129–2139. 10.1056/NEJMoa040938

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 52

  MaZ.HillD. A.CollinsM. H.MorrisS. W.SumegiJ.ZhouM.et al (2003). Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor.Genes Chromosomes Cancer3798–105. 10.1002/gcc.10177

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 53

  MaesakoY.IzumiK.OkamoriS.TakeokaK.KishimoriC.OkumuraA.et al (2014). inv(2)(p23q13)/RAN-binding protein 2 (RANBP2)-ALK fusion gene in myeloid leukemia that developed in an elderly woman.Int. J. Hematol.99202–207. 10.1007/s12185-013-1482-x

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 54

  MajewskiI. J.MittempergherL.DavidsonN. M.BosmaA.WillemsS. M.HorlingsH. M.et al (2013). Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing.J. Pathol.230270–276. 10.1002/path.4209

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 55

  Marino-EnriquezA.OuW. B.WeldonC. B.FletcherJ. A.Perez-AtaydeA. R. (2011). ALK rearrangement in sickle cell trait-associated renal medullary carcinoma.Genes Chromosomes Cancer50146–153. 10.1002/gcc.20839

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 56

  McFaddenD. G.Dias-SantagataD.SadowP. M.LynchK. D.LubitzC.DonovanS. E.et al (2014). Identification of oncogenic mutations and gene fusions in the follicular variant of papillary thyroid carcinoma.J. Clin. Endocrinol. Metab.99E2457–E2462. 10.1210/jc.2014-2611

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 57

  MeechS. J.McGavranL.OdomL. F.LiangX.MeltesenL.GumpJ.et al (2001). Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4–anaplastic lymphoma kinase gene fusion.Blood981209–1216. 10.1182/blood.V98.4.1209

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 58

  MitelmanF. (2000). Recurrent chromosome aberrations in cancer.Mutat. Res.462247–253. 10.1016/S1383-5742(00)00006-5

  • CrossRef
  • Google Scholar
  • View reference in article

• 59

  MitelmanF.JohanssonB.MertensF. (2007). The impact of translocations and gene fusions on cancer causation.Nat. Rev. Cancer7233–245. 10.1038/nrc2091

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 60

  MorrisS. W.KirsteinM. N.ValentineM. B.DittmerK. G.ShapiroD. N.SaltmanD. L.et al (1994). Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin’s lymphoma.Science2631281–1284. 10.1126/science.8122112

  • CrossRef
  • Google Scholar
  • View reference in article

• 61

  NakataT.KitamuraY.ShimizuK.TanakaS.FujimoriM.YokoyamaS.et al (1999). Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma.Genes Chromosomes Cancer.2597–103. 10.1002/(SICI)1098-2264(199906)25:2<97::AID-GCC4>3.0.CO;2-L

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 62

  NakaokuT.TsutaK.IchikawaH.ShiraishiK.SakamotoH.EnariM.et al (2014). Druggable oncogene fusions in invasive mucinous lung adenocarcinoma.Clin. Cancer Res.203087–3093. 10.1158/1078-0432.CCR-14-0107

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 63

  PaezJ. G.JanneP. A.LeeJ. C.TracyS.GreulichH.GabrielS.et al (2004). EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.Science3041497–1500. 10.1126/science.1099314

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 64

  PanagopoulosI.NilssonT.DomanskiH. A.IsakssonM.LindblomP.MertensF.et al (2006). Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.Int. J. Cancer1181181–1186. 10.1002/ijc.21490

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 65

  PaoW.MillerV.ZakowskiM.DohertyJ.PolitiK.SarkariaI.et al (2004). EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib.Proc. Natl. Acad. Sci. U.S.A.10113306–13311. 10.1073/pnas.0405220101

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 66

  PerotG.SoubeyranI.RibeiroA.BonhommeB.SavagnerF.Boutet-BouzamondoN.et al (2014). Identification of a recurrent STRN/ALK fusion in thyroid carcinomas.PLoS One9:e87170. 10.1371/journal.pone.0087170

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 67

  RenH.TanZ. P.ZhuX.CrosbyK.HaackH.RenJ. M.et al (2012). Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer.Cancer Res.723312–3323. 10.1158/0008-5472.CAN-11-3931

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 68

  RikovaK.GuoA.ZengQ.PossematoA.YuJ.HaackH.et al (2007). Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.Cell1311190–1203. 10.1016/j.cell.2007.11.025

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 69

  SaenkoV.RogounovitchT.Shimizu-YoshidaY.AbrosimovA.LushnikovE.RoumiantsevP.et al (2003). Novel tumorigenic rearrangement, Δrfp/ret, in a papillary thyroid carcinoma from externally irradiated patient.Mutat. Res.52781–90. 10.1016/S0027-5107(03)00056-3

  • CrossRef
  • Google Scholar
  • View reference in article

• 70

  SakamotoK.NakasoneH.TogashiY.SakataS.TsuyamaN.BabaS. (2016). ALK-positive large B-cell lymphoma: identification of EML4-ALK and a review of the literature focusing on the ALK immunohistochemical staining pattern.Int. J. Hematol.103399–408. 10.1007/s12185-016-1934-1

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 71

  SalassidisK.BruchJ.ZitzelsbergerH.LengfelderE.KellererA. M.BauchingerM. (2000). Translocation t(10;14)(q11.2:q22.1) fusing the kinetin to the RET gene creates a novel rearranged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma.Cancer Res.602786–2789.

  • Pubmed Abstract
  • Google Scholar
  • View reference in article

• 72

  SetoT.KiuraK.NishioM.NakagawaK.MaemondoM.InoueA.et al (2013). CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study.Lancet Oncol.14590–598. 10.1016/S1470-2045(13)70142-6

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 73

  ShawA. T.KimD. W.NakagawaK.SetoT.CrinoL.AhnM. J.et al (2013). Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.N. Engl. J. Med.3682385–2394. 10.1056/NEJMoa1214886

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 74

  ShigematsuH.LinL.TakahashiT.NomuraM.SuzukiM.WistubaI. I.et al (2005). Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.J. Natl. Cancer Inst.97339–346. 10.1093/jnci/dji055

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 75

  ShiotaM.FujimotoJ.SembaT.SatohH.YamamotoT.MoriS. (1994). Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3.Oncogene91567–1574.

  • Pubmed Abstract
  • Google Scholar
  • View reference in article

• 76

  SodaM.ChoiY. L.EnomotoM.TakadaS.YamashitaY.IshikawaS.et al (2007). Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.Nature448561–566. 10.1038/nature05945

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 77

  SongZ.YuX.ZhangY. (2017). Clinicopathological characteristics and survival of ALK, ROS1 and RET rearrangements in non-adenocarcinoma non-small cell lung cancer patients.Cancer Biol. Ther.18883–887. 10.1080/15384047.2016.1235660

  • Pubmed Abstract
  • CrossRef
  • Google Scholar
  • View reference in article

• 78

  StranskyN.CeramiE.SchalmS.KimJ. L.LengauerC. (2014). The landscape of kinase fusions in cancer.Nat. Commun.5:4846. 10.1038/ncomms5846

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 79

  SugawaraE.TogashiY.KurodaN.SakataS.HatanoS.AsakaR.et al (2012). Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method.Cancer1184427–4436. 10.1002/cncr.27391

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 80

  TakahashiM.RitzJ.CooperG. M. (1985). Activation of a novel human transforming gene, ret, by DNA rearrangement.Cell42581–588. 10.1016/0092-8674(85)90115-1

  • CrossRef
  • Google Scholar

• 81

  TakeuchiK.ChoiY. L.TogashiY.SodaM.HatanoS.InamuraK.et al (2009). KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer.Clin. Cancer Res.153143–3149. 10.1158/1078-0432.CCR-08-3248

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 82

  TakeuchiK.SodaM.TogashiY.OtaY.SekiguchiY.HatanoS.et al (2011). Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma.Haematologica96464–467. 10.3324/haematol.2010.033514

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 83

  TakeuchiK.SodaM.TogashiY.SuzukiR.SakataS.HatanoS.et al (2012). RET, ROS1 and ALK fusions in lung cancer.Nat. Med.18378–381. 10.1038/nm.2658

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 84

  TakeuchiK.TogashiY.KamiharaY.FukuyamaT.YoshiokaH.InoueA.et al (2016). Prospective and clinical validation of ALK immunohistochemistry: results from the phase I/II study of alectinib for ALK-positive lung cancer (AF-001JP study).Ann. Oncol.27185–192. 10.1093/annonc/mdv501

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 85

  TanD. S.-W.KimD.-W.ThomasM.PantanoS.WangY.SzpakowskiS. L.et al (2016). Genetic landscape of ALK+ non-small cell lung cancer (NSCLC) patients (pts) and response to ceritinib in ASCEND-1.J. Clin. Oncol.34(15 Suppl.)9064–9064. 10.1200/JCO.2016.34.15_suppl.9064

  • CrossRef
  • Google Scholar

• 86

  TogashiY.SodaM.SakataS.SugawaraE.HatanoS.AsakaR.et al (2012). KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only.PLoS One7:e31323. 10.1371/journal.pone.0031323

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 87

  TortF.PinyolM.PulfordK.RoncadorG.HernandezL.NayachI.et al (2001). Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma.Lab. Invest.81419–426. 10.1038/labinvest.3780249

  • CrossRef
  • Google Scholar

• 88

  TouriolC.GreenlandC.LamantL.PulfordK.BernardF.RoussetT.et al (2000). Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like).Blood953204–3207.

  • Pubmed Abstract
  • Google Scholar

• 89

  TsutaK.KohnoT.YoshidaA.ShimadaY.AsamuraH.FurutaK.et al (2014). RET-rearranged non-small-cell lung carcinoma: a clinicopathological and molecular analysis.Br. J. Cancer1101571–1578. 10.1038/bjc.2014.36

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 90

  TsuyamaN.SakamotoK.SakataS.DobashiA.TakeuchiK. (2017). Anaplastic large cell lymphoma: pathology, genetics, and clinical aspects.J. Clin. Exp. Hematop.57120–142. 10.3960/jslrt.17023

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 91

  Van RoosbroeckK.CoolsJ.DierickxD.ThomasJ.VandenbergheP.StulM.et al (2010). ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions.Haematologica95509–513. 10.3324/haematol.2009.014761

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 92

  VelchetiV.MadisonR.AliS. M.SchrockA. B. (2018). WAC/RET: a novel RET oncogenic fusion variant in non-small cell lung carcinoma.J. Thorac. Oncol.13e122–e123. 10.1016/j.jtho.2018.03.003

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 93

  VelchetiV.ThawaniR.KhungerM.MukhopadhyayS.ChuteD. J.SchrockA. B.et al (2017). FRMD4A/RET: a novel RET oncogenic fusion variant in non-small cell lung carcinoma.J. Thorac. Oncol.12e15–e16. 10.1016/j.jtho.2016.11.274

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 94

  WangR.HuH.PanY.LiY.YeT.LiC.et al (2012). RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer.J. Clin. Oncol.304352–4359. 10.1200/JCO.2012.44.1477

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 95

  WeinsteinI. B. (2002). Cancer. Addiction to oncogenes–the Achilles heal of cancer.Science29763–64. 10.1126/science.1073096

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 96

  YakirevichE.ResnickM. B.MangrayS.WheelerM.JacksonC. L.LombardoetK. A.et al (2016). Oncogenic ALK fusion in rare and aggressive subtype of colorectal adenocarcinoma as a potential therapeutic target.Clin. Cancer Res.223831–3840. 10.1158/1078-0432.CCR-15-3000

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 97

  ZhangX.LiY.LiuC.WangW.LiM.LvD.et al (2018). Identification of a novel KIF13A-RET fusion in lung adenocarcinoma by next-generation sequencing.Lung Cancer11827–29. 10.1016/j.lungcan.2017.08.019

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 98

  ZhengZ.LiebersM.ZhelyazkovaB.CaoY.PanditiD.LynchK. D.et al (2014). Anchored multiplex PCR for targeted next-generation sequencing.Nat. Med.201479–1484. 10.1038/nm.3729

  • Pubmed Abstract
  • CrossRef
  • Google Scholar