Due to a production error, there was a mistake in Table 1 as published. The references listed in the table were accidentally inverted. The corrected Table 1 appears below.
TABLE 1
| HCM mutation | Intrinsic force (Fintrinsic) | Velocity (v) | ATPase (kcat) | Number of available myosin heads (Na) | References |
|---|---|---|---|---|---|
| Change from wildtype human β-cardiac myosin | |||||
| R403Q | ↓ | ↑ | ↑ | ↑ | Nag et al. (2015), Nag et al. (2017), Sarkar et al. (2020) |
| R453C | ↑ | ↓ | ↓ | - | Sommese et al. (2013) Nag et al. (2017), Bloemink et al. (2014) |
| R719W | ↓ | ↑ | NC | ↑ | Kawana et al. (2017), Adhikari et al. (2019) |
| R723G | ↓ | ↑ | NC | - | Kawana et al. (2017) |
| G741R | NC | NC | NC | - | Kawana et al. (2017) |
| R663H | NC | NC | NC | ↑ | Sarkar et al. (2020) |
| R249Q | - | ↓ | ↓ | ↑ | Nag et al. (2017), Adhikari et al. (2019) |
| I457T | - | ↑ | ↑ | NC | Adhikari et al. (2019) |
| P710R | - * | ↓ | ↓ | ↑ | Vander Roest et al. (2021), Vera et al. (2019) |
| V763M | - | ↑ | NC | - | Vera et al. (2019) |
| H251N | ↑ | ↑ | ↑ | ↑ | Adhikari et al. (2016), Nag et al. (2017), Adhikari et al. (2019), Vera et al. (2019) |
| D239N | ↑ | ↑ | ↑ | - | Adhikari et al. (2016) |
| D778V | ↓** | ↑ | ↑ | ↑ | Morck et al. (2022) |
| L781P | NC** | ↓ | NC | ↑ | Morck et al. (2022) |
| S782N | ↓** | NC | NC | ↑ | Morck et al. (2022) |
| A797T | - | NC | NC | ↑ | Morck et al. (2022) |
| F834L | - | NC | NC | ↑ | Morck et al. (2022) |
Summary of the functional effect of HCM mutations in cardiac myosin.
Summary of HCM mutations that have been studied using the purified human cardiac myosin heavy chains and light chains. While Fintrinsic, v and kcat values showed no consistent trends among the HCM variants, the Na was increased in all tested variants. * The intrinsic force has not been measured for this mutation. Optical trapping using harmonic force spectroscopy showed a reduction in the step size of the mutant myosin motor and decreased load sensitivity of the actin detachment rate at the single molecule level. ** The intrinsic force has not been measured for this mutation. Optical trapping using harmonic force spectroscopy was used to obtain load-dependent detachment rate, load sensitivity and step size. The average force of the sarcomere was calculated using these parameters.
Due to a production error, the Reference for “Vera et al., 2019” was incorrectly written as “Vera, C. D., Johnson, C. A., Walklate, J., Adhikari, A., Svicevic, M., Mijailovich, S.M., et al. (2019). Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties. Biophysics. doi:10.1101/622738”. It should be “Vera, C. D., Johnson, C. A., Walklate, J., Adhikari, A., Svicevic, M., Mijailovich, S.M., et al. (2019). Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties. Biophysics. doi:10.1074/jbc.RA119.010563”. The publisher apologizes for this mistake. The original version of this article has been updated.
Summary
Keywords
myosin, hypertrophic cardiomyopathy, super relaxed state, mavacamten, omecamtiv mercarbil
Citation
Frontiers Production Office (2022) Erratum: Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies. Front. Physiol. 13:1111059. doi: 10.3389/fphys.2022.1111059
Received
29 November 2022
Accepted
29 November 2022
Published
12 December 2022
Approved by
Frontiers Editorial Office, Frontiers Media SA, Switzerland
Volume
13 - 2022
Updates
Copyright
© 2022 Frontiers Production Office.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Frontiers Production Office, production.office@frontiersin.org
This article was submitted to Striated Muscle Physiology, a section of the journal Frontiers in Physiology
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