ORIGINAL RESEARCH article

Front. Physiol.

Sec. Metabolic Physiology

Volume 16 - 2025 | doi: 10.3389/fphys.2025.1463597

Identification of potential miRNA biomarkers for neurobrucellosis diagnosis

Provisionally accepted
Meiling LiuMeiling Liu1Liping FengLiping Feng2Shujun ShiShujun Shi1Yuzhou GuoYuzhou Guo1Menghan LvMenghan Lv1Zhengyu LiZhengyu Li1Xintian WangXintian Wang1Hao YangHao Yang1Zhelin ZhangZhelin Zhang1*
  • 1Affiliated Hospital, Inner Mongolia Medical University, Hohhot, China
  • 2Xing'an League Disease Prevention and Control Center, Ulanhot,, China

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In this research, we identified four potential biomarkers (miR-342-3p, miR-576-5p, miR-15b-5p, and miR-499a-5p) for diagnosing NB. Furthermore, we developed a new diagnostic signature for NB using two miRNAs (miR-576-5p and miR-499a-5p). This signature demonstrated promising diagnostic capabilities in both in-house and validation cohorts. The discovery of reliable biomarkers is crucial for the early and precise detection of neurological disorders. We believe that our findings may provide valuable contributions to the field of NB research.

Keywords: Neurobrucellosis, miRNAs, Cerebrospinal fluids, miR-499a-5p, miR-576-5p

Received: 12 Jul 2024; Accepted: 18 Feb 2025.

Copyright: © 2025 Liu, Feng, Shi, Guo, Lv, Li, Wang, Yang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Zhelin Zhang, Affiliated Hospital, Inner Mongolia Medical University, Hohhot, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material