REVIEW article
Front. Physiol.
Sec. Exercise Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1568334
Importance of Selected Genetic Determinants on Endurance Performance and Physical Strength: A Narrative Review
Provisionally accepted
Jiawei Yao1
Falguni Saraf2Vishan Singh Rathore2
Kinan Darkazanli3
Liu Yubo4
Mallikarjuna KORIVI4*
Bhaskar LVKS2*- 1Guangdong Vocational Academy of Art, Foshan, China
- 2Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India
- 3Ural State Technical University, Yekaterinburg, Russia
- 4Zhejiang Normal University, Jinhua, Zhejiang Province, China
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Physical strength and endurance of an individual are vital for athletic performance, and minimizing the risk of injuries, especially during competitions. Other than training and diet, athletic performance is determined by genetic factors or heredity, which is less focused in sports science research. Genetic factors play a crucial role in greater cardiovascular endurance and muscular phenotypes, and thereby contribute to athletic success. Several genes and different polymorphisms are positively/negatively associated with athletic performance. This review delved into the intricate role of several genes and polymorphisms in different-population groups, and explored their impact on an individual's ability to engage in athletic activities. Among several identified genes, the prominent genes, including ACE, AGT, BDKRB2, NOS3, HIF1A, ACTN3, AMPD1, PPARGC1, SOD2, BDNF, VDR and mtDNA are discussed in this study. These genes have been reported to play indispensable roles in endurance performance and power. Furthermore, genetic variations/polymorphisms within these genes are potential to impact various aspects of physiology, including cardiovascular function, muscle fiber composition, and metabolic efficiency. Genetic polymorphisms are recognized as contributing factors in determining the athletic capacity to engage and perform sustained physical activities in their respective sports. We emphasized the noteworthy discoveries from the existing literature, and precisely explored the association between particular gene polymorphisms and athletic prowess, with a specific focus on endurance-oriented sports (running, cycling, and swimming) and power sports. Understanding the genetic variations and their influence on endurance/power sports can offer valuable insights for athletes, coaches, and scientists in sports sciences, who strive to enhance athletic training strategies and performance outcomes in achieving success.
Keywords: Endurance, Athletic Performance, polymorphisms, angiotensin-converting enzyme, power, allele
Received: 29 Jan 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Yao, Saraf, Singh Rathore, Darkazanli, Yubo, KORIVI and LVKS. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mallikarjuna KORIVI, Zhejiang Normal University, Jinhua, 321004, Zhejiang Province, China
Bhaskar LVKS, Guru Ghasidas Vishwavidyalaya, Bilaspur, 495 009, Chhattisgarh, India
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.