ORIGINAL RESEARCH article
Front. Physiol.
Sec. Vascular Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1575128
Acute treatment witheffect of statins does not affecton vascular reactivity in maternal and placental arteries from pregnancies complicated by pre-eclampsia
Provisionally accepted
- 1Brunel University London, Uxbridge, United Kingdom
- 2The University of Manchester, Manchester, England, United Kingdom
- 3Saint Mary's Hospital, Manchester University NHS Foundation Trust (MFT), Manchester, United Kingdom
- 4Manchester Academic Health Science Centre (MAHSC), Manchester, United Kingdom
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This study hypothesised that acute statin exposure would improveaimed to investigate the acute effects of statins on omentalmaternal and fetoplacental arteryvascular functionreactivity in in PE without demonstrating detrimental effects on fetoplacental vessels from pregnancies affected by pre-eclampsia (PE)., Pre-eclampsia (PE), which affects 4-5% of pregnancies, is defined as new-onset hypertension and proteinuria post-20 weeks of gestation and is a leading cause of maternal and fetal morbidity and mortality. There are no effective therapies response curves with NO-donor SNP or endothelium-dependent bradykinin (BK) performed following U46619 pre-constriction.CPAs from normal and PE pregnancies showed similar responses following exposure to the vasoconstrictive agent U46619 and the relaxatory agent SNP. Short-term exposure to pravastatin, simvastatin and pitavastatin did not cause detrimental effects on CPA reactivity.Acute exposure of OAs from PE pregnancies to pitavastatin (1 µM) did not reduce U46619mediated contraction or enhance BK-mediated relaxation of vessels although in this study ex vivo endothelial function of OAs from PE pregnancies was not different to those in normotensive pregnancy pre incubation .In conclusion, this study did not demonstrate an effect on vascular reactivity of maternal systemic or fetoplacental arteries following acute treatment of statins. In order toTo investigate the potential of this drug to treat pre-eclampsia,Future studies investigating the effect of longer-term statin exposure on maternal and fetoplacental vascular reactivity function may help towards treatment strategies for vascular dysfunction in PE-affected patientsand investigation of maternal-fetal drug transfer are needed.
Keywords: Pre-Eclampsia, Statins, Pregnancy, Vascular function, Therapeutics
Received: 11 Feb 2025; Accepted: 22 Apr 2025.
Copyright: © 2025 Agwu, Myers, Dilworth and Wareing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chinedu Agwu, Brunel University London, Uxbridge, United Kingdom
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