ORIGINAL RESEARCH article
Front. Physiol.
Sec. Vascular Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1587635
Cardiovascular Disease and Depression as Mediators Between Red Blood Cell Distribution Width to Albumin Ratio and Cognitive Impairment in Older Adults
Provisionally accepted
- 1Xuanwu Hospital, Capital Medical University, Beijing, China
- 2Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
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Background: Cognitive impairment is a major public health concern in aging populations, and early identification of risk factors is critical. The red blood cell distribution width to albumin ratio (RAR) has emerged as a potential biomarker reflecting inflammatory and nutritional status, but its association with cognitive impairment remains unclear.Objective: This study investigates the relationship between RAR and cognitive impairment in older adults, and explores potential mediating variables that may influence this association.: A total of 2,913 participants aged ≥60 years from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 cycles were analyzed, including 1,291 with cognitive impairment. Logistic regression assessed the association between RAR and cognitive impairment, adjusting for potential confounders such as age, gender, race, This study investigates the relationship between RAR and cognitive impairment in older adults.
Keywords: red blood cell distribution width/albumin ratio, cognitive impairment, NHANES, older adults, cardiovascular disease, Depression
Received: 05 Mar 2025; Accepted: 26 May 2025.
Copyright: © 2025 Wang, Bai, Wang, Wu, Pan, Guo, Yu, Guo and Gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hui Wang, Xuanwu Hospital, Capital Medical University, Beijing, China
Peng Yu, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
Jianming Guo, Xuanwu Hospital, Capital Medical University, Beijing, China
Yongquan Gu, Xuanwu Hospital, Capital Medical University, Beijing, China
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