ORIGINAL RESEARCH article

Front. Physiol.

Sec. Computational Physiology and Medicine

Volume 16 - 2025 | doi: 10.3389/fphys.2025.1598850

This article is part of the Research TopicMedical Knowledge-Assisted Machine Learning Technologies in Individualized Medicine Volume IIView all 16 articles

Weakly supervised multiple instance active learning for tooth-marked tongue recognition

Provisionally accepted
  • School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, China

The final, formatted version of the article will be published soon.

The recognition of tooth-marked tongue has important clinical diagnostic value in Traditional Chinese Medicine. Current deep learning methods for tooth mark detection require extensive manual labeling and tongue segmentation, which is labor-intensive. Therefore, we propose a weakly supervised multiple instance active learning model for tooth-marked tongue recognition, aiming to eliminate preprocessing segmentation and reduce the annotation workload while maintaining diagnostic accuracy. We propose a one-stage method to generate tooth mark instances, which eliminates the need for pre-segmentation of the tongue. To make full use of unlabeled data, we introduce a semi-supervised learning paradigm to pseudo label unlabeled tongue images with high model confidence in active learning and incorporate them into the training set, so as to improve the training efficiency of active learning model. In addition, We propose an instance-level hybrid query method considering the diversity of tooth marks. Experimental results on clinical tongue images verify the effectiveness of the proposed method, which achieves an accuracy of 93.88% for tooth-marked tongue recognition, outperforming the recently introduced weakly supervised approaches.

Keywords: Tooth-marked tongue, Weakly supervised learning, Multiple Instance Learning, Active Learning, Pseudo label

Received: 24 Mar 2025; Accepted: 05 May 2025.

Copyright: © 2025 Deng, Li, Yang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Wu Zhou, School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China

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